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High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KCNH2: Deep mutational scan of KCNH2 trafficking
Krystian A. Kozek, Andrew M. Glazer, Chai-Ann Ng, Daniel Blackwell, Christian L. Egly, Loren R. Vanags, Marcia Blair, Devyn Mitchell, Kenneth A. Matreyek, Douglas M. Fowler, Bjorn C. Knollmann, View ORCID ProfileJamie Vandenberg, Dan M. Roden, Brett M. Kroncke
doi: https://doi.org/10.1101/2020.02.17.952606
Krystian A. Kozek
1Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Ph.D.Andrew M. Glazer
1Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Ph.D.Chai-Ann Ng
2Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
3St Vincent’s Clinical School, UNSW Sydney, Darlinghurst, New South Wales, Australia
Ph.D.Daniel Blackwell
1Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Ph.D.Christian L. Egly
1Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
PharmD.Loren R. Vanags
1Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
B.S.Marcia Blair
1Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
B.S.Devyn Mitchell
1Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
B.S.Kenneth A. Matreyek
4Department of Genome Sciences, University of Washington, Seattle, WA, USA
6Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Ph.D.Douglas M. Fowler
4Department of Genome Sciences, University of Washington, Seattle, WA, USA
5Department of Bioengineering, University of Washington, Seattle, WA, USA
Ph.D.Bjorn C. Knollmann
1Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
M.D, Ph.D.Jamie Vandenberg
2Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
3St Vincent’s Clinical School, UNSW Sydney, Darlinghurst, New South Wales, Australia
Ph.D.Dan M. Roden
1Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
M.D.Brett M. Kroncke
1Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Ph.D.
Posted February 17, 2020.
High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KCNH2: Deep mutational scan of KCNH2 trafficking
Krystian A. Kozek, Andrew M. Glazer, Chai-Ann Ng, Daniel Blackwell, Christian L. Egly, Loren R. Vanags, Marcia Blair, Devyn Mitchell, Kenneth A. Matreyek, Douglas M. Fowler, Bjorn C. Knollmann, Jamie Vandenberg, Dan M. Roden, Brett M. Kroncke
bioRxiv 2020.02.17.952606; doi: https://doi.org/10.1101/2020.02.17.952606
High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KCNH2: Deep mutational scan of KCNH2 trafficking
Krystian A. Kozek, Andrew M. Glazer, Chai-Ann Ng, Daniel Blackwell, Christian L. Egly, Loren R. Vanags, Marcia Blair, Devyn Mitchell, Kenneth A. Matreyek, Douglas M. Fowler, Bjorn C. Knollmann, Jamie Vandenberg, Dan M. Roden, Brett M. Kroncke
bioRxiv 2020.02.17.952606; doi: https://doi.org/10.1101/2020.02.17.952606
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