X-ray Structure of Main Protease of the Novel Coronavirus SARS-CoV-2 Enables Design of α-Ketoamide Inhibitors

Linlin Zhang; Daizong Lin; Xinyuanyuan Sun; Katharina Rox; Rolf Hilgenfeld

doi:10.1101/2020.02.17.952879

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X-ray Structure of Main Protease of the Novel Coronavirus SARS-CoV-2 Enables Design of α-Ketoamide Inhibitors

Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, Katharina Rox, View ORCID ProfileRolf Hilgenfeld

doi: https://doi.org/10.1101/2020.02.17.952879

Linlin Zhang

1Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

2German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck, 23562 Lübeck, Germany

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Daizong Lin

1Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

3Changchun Discovery Sciences, 789 Shunda Rd., Changchun, Jilin 130012, China

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Xinyuanyuan Sun

1Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

2German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck, 23562 Lübeck, Germany

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Katharina Rox

4Department of Chemical Biology, Helmholtz Center for Infection Research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany

5German Center for Infection Research (DZIF), Hannover – Braunschweig Site, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany

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Rolf Hilgenfeld

1Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

2German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck, 23562 Lübeck, Germany

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ORCID record for Rolf Hilgenfeld
For correspondence: rolf.hilgenfeld@uni-luebeck.de

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Posted February 20, 2020.

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X-ray Structure of Main Protease of the Novel Coronavirus SARS-CoV-2 Enables Design of α-Ketoamide Inhibitors

Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, Katharina Rox, Rolf Hilgenfeld

bioRxiv 2020.02.17.952879; doi: https://doi.org/10.1101/2020.02.17.952879

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X-ray Structure of Main Protease of the Novel Coronavirus SARS-CoV-2 Enables Design of α-Ketoamide Inhibitors

Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, Katharina Rox, Rolf Hilgenfeld

bioRxiv 2020.02.17.952879; doi: https://doi.org/10.1101/2020.02.17.952879

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