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X-ray Structure of Main Protease of the Novel Coronavirus SARS-CoV-2 Enables Design of α-Ketoamide Inhibitors
Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, Katharina Rox, View ORCID ProfileRolf Hilgenfeld
doi: https://doi.org/10.1101/2020.02.17.952879
Linlin Zhang
1Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
2German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck, 23562 Lübeck, Germany
Daizong Lin
1Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
3Changchun Discovery Sciences, 789 Shunda Rd., Changchun, Jilin 130012, China
Xinyuanyuan Sun
1Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
2German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck, 23562 Lübeck, Germany
Katharina Rox
4Department of Chemical Biology, Helmholtz Center for Infection Research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany
5German Center for Infection Research (DZIF), Hannover – Braunschweig Site, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany
Rolf Hilgenfeld
1Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
2German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck, 23562 Lübeck, Germany

- Supplementary materials[supplements/952879_file02.pdf]
Posted February 20, 2020.
X-ray Structure of Main Protease of the Novel Coronavirus SARS-CoV-2 Enables Design of α-Ketoamide Inhibitors
Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, Katharina Rox, Rolf Hilgenfeld
bioRxiv 2020.02.17.952879; doi: https://doi.org/10.1101/2020.02.17.952879
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