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Behavioral features of motivated response to alcohol in Drosophila

Jamie L. Catalano, Nicholas Mei, Reza Azanchi, Sophia Song, Tyler Blackwater, Ulrike Heberlein, Karla R. Kaun
doi: https://doi.org/10.1101/2020.02.17.953026
Jamie L. Catalano
aMolecular Pharmacology and Physiology Graduate Program, Brown University, Providence, RI, USA
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Nicholas Mei
bDepartment of Neuroscience, Brown University, Providence, RI, USA
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Reza Azanchi
bDepartment of Neuroscience, Brown University, Providence, RI, USA
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Sophia Song
bDepartment of Neuroscience, Brown University, Providence, RI, USA
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Tyler Blackwater
bDepartment of Neuroscience, Brown University, Providence, RI, USA
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Ulrike Heberlein
cHoward Hughes Medical Institute, Janelia Research Campus (HHMI JRC), Ashburn, VA, USA
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Karla R. Kaun
bDepartment of Neuroscience, Brown University, Providence, RI, USA
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  • For correspondence: karla_kaun@brown.edu
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Abstract

Animals avoid predators and find the best food and mates by learning from the consequences of their behavior. However, reinforcers are not always uniquely appetitive or aversive but can have complex properties. Most intoxicating substances fall within this category; provoking aversive sensory and physiological reactions while simultaneously inducing overwhelming appetitive properties. Here we describe the subtle behavioral features associated with continued seeking for alcohol despite aversive consequences. We developed an automated runway apparatus to measure how Drosophila respond to consecutive exposures of a volatilized substance. Behavior within this Behavioral Expression of Ethanol Reinforcement Runway (BEER Run) demonstrated a defined shift from aversive to appetitive responses to volatilized ethanol. Behavioral metrics attained by combining computer vision and machine learning methods, reveal that a subset of 9 classified behaviors and component behavioral features associate with this shift. We propose this combination of 9 behaviors can be used to navigate the complexities of operant learning to reveal motivated goal-seeking behavior.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 17, 2020.
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Behavioral features of motivated response to alcohol in Drosophila
Jamie L. Catalano, Nicholas Mei, Reza Azanchi, Sophia Song, Tyler Blackwater, Ulrike Heberlein, Karla R. Kaun
bioRxiv 2020.02.17.953026; doi: https://doi.org/10.1101/2020.02.17.953026
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Behavioral features of motivated response to alcohol in Drosophila
Jamie L. Catalano, Nicholas Mei, Reza Azanchi, Sophia Song, Tyler Blackwater, Ulrike Heberlein, Karla R. Kaun
bioRxiv 2020.02.17.953026; doi: https://doi.org/10.1101/2020.02.17.953026

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