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Spatial maps in piriform cortex during olfactory navigation

View ORCID ProfileCindy Poo, Gautam Agarwal, View ORCID ProfileNiccolò Bonacchi, View ORCID ProfileZachary Mainen
doi: https://doi.org/10.1101/2020.02.18.935494
Cindy Poo
1Champalimaud Foundation, Lisbon, Portugal
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  • For correspondence: cindy.poo@neuro.fchampalimaud.org zmainen@neuro.fchampalimaud.org
Gautam Agarwal
2Redwood Center for Theoretical Neuroscience, University of California, Berkeley, CA, USA
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Niccolò Bonacchi
1Champalimaud Foundation, Lisbon, Portugal
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Zachary Mainen
1Champalimaud Foundation, Lisbon, Portugal
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  • For correspondence: cindy.poo@neuro.fchampalimaud.org zmainen@neuro.fchampalimaud.org
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Summary

Odors are a fundamental part of the sensory environment used by animals to inform behaviors such as foraging and navigation1, 2. Primary olfactory (piriform) cortex is thought to be dedicated to encoding odor identity3–8. Here, using neural ensemble recordings in freely moving rats performing a novel odor-cued spatial choice task, we show that posterior piriform cortex neurons also carry a robust spatial map of the environment. Piriform spatial maps were stable across behavioral contexts independent of olfactory drive or reward availability, and the accuracy of spatial information carried by individual neurons depended on the strength of their functional coupling to the hippocampal theta rhythm. Ensembles of piriform neurons concurrently represented odor identity as well as spatial locations of animals, forming an “olfactory-place map”. Our results reveal a previously unknown function for piriform cortex in spatial cognition and suggest that it is well-suited to form odor-place associations and guide olfactory cued spatial navigation.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 05, 2021.
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Spatial maps in piriform cortex during olfactory navigation
Cindy Poo, Gautam Agarwal, Niccolò Bonacchi, Zachary Mainen
bioRxiv 2020.02.18.935494; doi: https://doi.org/10.1101/2020.02.18.935494
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Spatial maps in piriform cortex during olfactory navigation
Cindy Poo, Gautam Agarwal, Niccolò Bonacchi, Zachary Mainen
bioRxiv 2020.02.18.935494; doi: https://doi.org/10.1101/2020.02.18.935494

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