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Mapping human laryngeal motor cortex during vocalization

View ORCID ProfileNicole Eichert, Daniel Papp, Rogier B. Mars, Kate E. Watkins
doi: https://doi.org/10.1101/2020.02.20.958314
Nicole Eichert
1Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
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  • For correspondence: nicole.eichert@psy.ox.ac.uk
Daniel Papp
1Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
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Rogier B. Mars
1Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
2Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
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Kate E. Watkins
3Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
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Abstract

The representations of the articulators involved in human speech production are organized somatotopically in primary motor cortex. The neural representation of the larynx, however, remains debated. Both a dorsal and a ventral larynx representation have been previously described. It is unknown, however, whether both representations are located in primary motor cortex. Here, we mapped the motor representations of the human larynx using fMRI and characterized the cortical microstructure underlying the activated regions. We isolated brain activity related to laryngeal activity during vocalization while controlling for breathing. We also mapped the articulators (the lips and tongue) and the hand area. We found two separate activations during vocalization – a dorsal and a ventral larynx representation. Structural and quantitative neuroimaging revealed that myelin content and cortical thickness underlying the dorsal, but not the ventral larynx representation, are similar to those of other primary motor representations. This finding confirms that the dorsal larynx representation is located in primary motor cortex and that the ventral one is not. We further speculate that the location of the ventral larynx representation is in premotor cortex, as seen in other primates. It remains unclear, however, whether and how these two representations differentially contribute to laryngeal motor control.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Major revisions to manuscript text and figures.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted June 01, 2020.
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Mapping human laryngeal motor cortex during vocalization
Nicole Eichert, Daniel Papp, Rogier B. Mars, Kate E. Watkins
bioRxiv 2020.02.20.958314; doi: https://doi.org/10.1101/2020.02.20.958314
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Mapping human laryngeal motor cortex during vocalization
Nicole Eichert, Daniel Papp, Rogier B. Mars, Kate E. Watkins
bioRxiv 2020.02.20.958314; doi: https://doi.org/10.1101/2020.02.20.958314

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