An autoimmune disease risk variant has a trans master regulatory effect mediated by IRF1 under immune stimulation

Margot Brandt; Sarah Kim-Hellmuth; Marcello Ziosi; Alper Gokden; Aaron Wolman; Nora Lam; Yocelyn Recinos; Veit Hornung; Johannes Schumacher; Tuuli Lappalainen

doi:10.1101/2020.02.21.959734

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An autoimmune disease risk variant has a trans master regulatory effect mediated by IRF1 under immune stimulation

Margot Brandt, Sarah Kim-Hellmuth, Marcello Ziosi, Alper Gokden, Aaron Wolman, Nora Lam, Yocelyn Recinos, Veit Hornung, Johannes Schumacher, View ORCID ProfileTuuli Lappalainen

doi: https://doi.org/10.1101/2020.02.21.959734

Margot Brandt

1New York Genome Center, New York, NY, USA

2Department of Systems Biology, Columbia University, New York, NY, USA

3Integrated Program in Cellular, Molecular, and Biomedical Studies, Columbia University, New York, NY, USA

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Sarah Kim-Hellmuth

1New York Genome Center, New York, NY, USA

2Department of Systems Biology, Columbia University, New York, NY, USA

4Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany

5Dr. von Hauner Children’s Hospital, Department of Pediatrics, University Hospital LMU Munich, Munich, Germany

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Marcello Ziosi

1New York Genome Center, New York, NY, USA

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Alper Gokden

1New York Genome Center, New York, NY, USA

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Aaron Wolman

1New York Genome Center, New York, NY, USA

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Nora Lam

1New York Genome Center, New York, NY, USA

6Program of Pathobiology and Mechanisms of Disease, Columbia University, New York, NY, USA

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Yocelyn Recinos

1New York Genome Center, New York, NY, USA

2Department of Systems Biology, Columbia University, New York, NY, USA

3Integrated Program in Cellular, Molecular, and Biomedical Studies, Columbia University, New York, NY, USA

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Veit Hornung

7Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany

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Johannes Schumacher

8Center for Human Genetics, University Hospital Marburg, Marburg, Germany

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Tuuli Lappalainen

1New York Genome Center, New York, NY, USA

2Department of Systems Biology, Columbia University, New York, NY, USA

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ORCID record for Tuuli Lappalainen
For correspondence: tlappalainen@nygenome.org

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Posted February 24, 2020.

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An autoimmune disease risk variant has a trans master regulatory effect mediated by IRF1 under immune stimulation

Margot Brandt, Sarah Kim-Hellmuth, Marcello Ziosi, Alper Gokden, Aaron Wolman, Nora Lam, Yocelyn Recinos, Veit Hornung, Johannes Schumacher, Tuuli Lappalainen

bioRxiv 2020.02.21.959734; doi: https://doi.org/10.1101/2020.02.21.959734

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An autoimmune disease risk variant has a trans master regulatory effect mediated by IRF1 under immune stimulation

Margot Brandt, Sarah Kim-Hellmuth, Marcello Ziosi, Alper Gokden, Aaron Wolman, Nora Lam, Yocelyn Recinos, Veit Hornung, Johannes Schumacher, Tuuli Lappalainen

bioRxiv 2020.02.21.959734; doi: https://doi.org/10.1101/2020.02.21.959734

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