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Thermodynamic and kinetic design principles for protein aggregation inhibitors
Thomas C. T. Michaels, View ORCID ProfileAndela Šarić, Georg Meisl, Gabriella T. Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher M. Dobson, Michele Vendruscolo, Tuomas P. J. Knowles
doi: https://doi.org/10.1101/2020.02.22.960716
Thomas C. T. Michaels
†Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
‡Paulson School of Engineering and Applied Science, Harvard University, Cambridge, Massachusetts 02138, USA
Andela Šarić
¶Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, Gower Street, London WC1E 6BT, UK
§MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London, WC1E 6BT, UK
Georg Meisl
†Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
Gabriella T. Heller
†Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
Samo Curk
¶Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, Gower Street, London WC1E 6BT, UK
§MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London, WC1E 6BT, UK
Paolo Arosio
‖Department of Chemistry and Applied Biosciences, ETH Zurich, Switzerland
Sara Linse
⊥Department of Chemistry, Division for Biochemistry and Structural Biology, Lund University, 221 00 Lund, Sweden
Christopher M. Dobson
†Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
Michele Vendruscolo
†Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
Tuomas P. J. Knowles
†Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
#Cavendish Laboratory, Department of Physics, University of Cambridge, J J Thomson Avenue, Cambridge, CB3 1HE, UK
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Posted February 24, 2020.
Thermodynamic and kinetic design principles for protein aggregation inhibitors
Thomas C. T. Michaels, Andela Šarić, Georg Meisl, Gabriella T. Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher M. Dobson, Michele Vendruscolo, Tuomas P. J. Knowles
bioRxiv 2020.02.22.960716; doi: https://doi.org/10.1101/2020.02.22.960716
Thermodynamic and kinetic design principles for protein aggregation inhibitors
Thomas C. T. Michaels, Andela Šarić, Georg Meisl, Gabriella T. Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher M. Dobson, Michele Vendruscolo, Tuomas P. J. Knowles
bioRxiv 2020.02.22.960716; doi: https://doi.org/10.1101/2020.02.22.960716
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