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The wiring logic of an identified serotonergic neuron that spans sensory networks

View ORCID ProfileKaylynn E. Coates, Steven A. Calle-Schuler, Levi M. Helmick, Victoria L. Knotts, Brennah N. Martik, Farzaan Salman, Lauren T. Warner, Sophia V. Valla, View ORCID ProfileDavi D. Bock, View ORCID ProfileAndrew M. Dacks
doi: https://doi.org/10.1101/2020.02.24.963660
Kaylynn E. Coates
1Department of Biology, West Virginia University, Morgantown, WV 26506, USA
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  • ORCID record for Kaylynn E. Coates
  • For correspondence: kaylynn.coates@gmail.com amdacks@mail.wvu.edu
Steven A. Calle-Schuler
2Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA
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Levi M. Helmick
1Department of Biology, West Virginia University, Morgantown, WV 26506, USA
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Victoria L. Knotts
1Department of Biology, West Virginia University, Morgantown, WV 26506, USA
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Brennah N. Martik
1Department of Biology, West Virginia University, Morgantown, WV 26506, USA
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Farzaan Salman
1Department of Biology, West Virginia University, Morgantown, WV 26506, USA
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Lauren T. Warner
1Department of Biology, West Virginia University, Morgantown, WV 26506, USA
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Sophia V. Valla
1Department of Biology, West Virginia University, Morgantown, WV 26506, USA
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Davi D. Bock
2Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA
3Department of Neurological Sciences, Larner College of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
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Andrew M. Dacks
1Department of Biology, West Virginia University, Morgantown, WV 26506, USA
4Department of Neuroscience, West Virginia University, Morgantown, WV 26506, USA
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  • For correspondence: kaylynn.coates@gmail.com amdacks@mail.wvu.edu
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Abstract

Serotonergic neurons modulate diverse physiological and behavioral processes in a context-dependent manner, based on their complex connectivity. However, their connectivity has not been comprehensively explored at a single-cell resolution. Using a whole-brain EM dataset we determined the wiring logic of a broadly projecting serotonergic neuron (the “CSDn”) in Drosophila. Within the antennal lobe (AL; first-order olfactory region), the CSDn receives glomerulus-specific input and preferentially targets distinct local interneuron subtypes. Furthermore, the wiring logic of the CSDn differs between olfactory regions. The CSDn innervates the AL and lateral horn (LH), yet does not maintain the same synaptic relationship with individual projection neurons that also span both regions. Consistent with this, the CSDn has more distributed connectivity in the LH relative to the AL, preferentially synapsing with principal neuron types based on presumptive transmitter content. Lastly, we identify protocerebral neurons that provide abundant synaptic input to the CSDn. Our study demonstrates how an individual modulatory neuron can interact with local networks and integrate input from non-olfactory sources.

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  • Competing Interests: The authors declare that no competing interests exist.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 25, 2020.
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The wiring logic of an identified serotonergic neuron that spans sensory networks
Kaylynn E. Coates, Steven A. Calle-Schuler, Levi M. Helmick, Victoria L. Knotts, Brennah N. Martik, Farzaan Salman, Lauren T. Warner, Sophia V. Valla, Davi D. Bock, Andrew M. Dacks
bioRxiv 2020.02.24.963660; doi: https://doi.org/10.1101/2020.02.24.963660
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The wiring logic of an identified serotonergic neuron that spans sensory networks
Kaylynn E. Coates, Steven A. Calle-Schuler, Levi M. Helmick, Victoria L. Knotts, Brennah N. Martik, Farzaan Salman, Lauren T. Warner, Sophia V. Valla, Davi D. Bock, Andrew M. Dacks
bioRxiv 2020.02.24.963660; doi: https://doi.org/10.1101/2020.02.24.963660

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