Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Oxytocin Acts on Astrocytes in the Central Amygdala to Promote a Positive Emotional State

Jérôme Wahis, Damien Kerspern, Ferdinand Althammer, Angel Baudon, Stéphanie Goyon, Daisuke Hagiwara, Arthur Lefèvre, Benjamin Boury-Jamot, Benjamin Bellanger, Marios Abatis, Miriam Silva da Gouveia, Diego Benusiglio, Marina Eliava, Andrej Rozov, Ivan Weinsanto, Hanna Sophie Knobloch-Bollmann, Hong Wang, Marie Pertin, Perrine Inquimbert, Claudia Pitzer, Jan Siemens, Yannick Goumon, Benjamin Boutrel, Pascal Darbon, Christophe Maurice Lamy, Javier E. Stern, Isabelle Décosterd, Jean-Yves Chatton, W. Scott Young, Ron Stoop, Pierrick Poisbeau, Valery Grinevich, Alexandre Charlet
doi: https://doi.org/10.1101/2020.02.25.963884
Jérôme Wahis
1Centre National de la Recherche Scientifique and University of Strasbourg, UPR3212 Institute of Cellular and Integrative Neurosciences, Strasbourg, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Damien Kerspern
1Centre National de la Recherche Scientifique and University of Strasbourg, UPR3212 Institute of Cellular and Integrative Neurosciences, Strasbourg, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ferdinand Althammer
2German Cancer Research Center (DKFZ), Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Angel Baudon
1Centre National de la Recherche Scientifique and University of Strasbourg, UPR3212 Institute of Cellular and Integrative Neurosciences, Strasbourg, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stéphanie Goyon
1Centre National de la Recherche Scientifique and University of Strasbourg, UPR3212 Institute of Cellular and Integrative Neurosciences, Strasbourg, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daisuke Hagiwara
3Department of Neuropeptide Research for Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arthur Lefèvre
3Department of Neuropeptide Research for Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benjamin Boury-Jamot
4Center for Psychiatric Neurosciences, Hôpital de Cery, Lausanne University Hospital (CHUV), Lausanne, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benjamin Bellanger
1Centre National de la Recherche Scientifique and University of Strasbourg, UPR3212 Institute of Cellular and Integrative Neurosciences, Strasbourg, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marios Abatis
4Center for Psychiatric Neurosciences, Hôpital de Cery, Lausanne University Hospital (CHUV), Lausanne, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Miriam Silva da Gouveia
2German Cancer Research Center (DKFZ), Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Diego Benusiglio
3Department of Neuropeptide Research for Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marina Eliava
3Department of Neuropeptide Research for Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrej Rozov
5OpenLab of Neurobiology, Kazan Federal University, Kazan, Russia and Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ivan Weinsanto
1Centre National de la Recherche Scientifique and University of Strasbourg, UPR3212 Institute of Cellular and Integrative Neurosciences, Strasbourg, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hanna Sophie Knobloch-Bollmann
6Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hong Wang
7Department of Pharmacology, Heidelberg University, Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marie Pertin
8Pain center, Department of Anesthesiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Perrine Inquimbert
1Centre National de la Recherche Scientifique and University of Strasbourg, UPR3212 Institute of Cellular and Integrative Neurosciences, Strasbourg, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Claudia Pitzer
9Interdisciplinary Neurobehavioral Core (INBC), Ruprecht-Karls-Universität, Heidelberg
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jan Siemens
7Department of Pharmacology, Heidelberg University, Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yannick Goumon
1Centre National de la Recherche Scientifique and University of Strasbourg, UPR3212 Institute of Cellular and Integrative Neurosciences, Strasbourg, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benjamin Boutrel
4Center for Psychiatric Neurosciences, Hôpital de Cery, Lausanne University Hospital (CHUV), Lausanne, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pascal Darbon
1Centre National de la Recherche Scientifique and University of Strasbourg, UPR3212 Institute of Cellular and Integrative Neurosciences, Strasbourg, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christophe Maurice Lamy
10Division of Anatomy, Faculty of Medicine, University of Geneva, Geneva, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Javier E. Stern
11Center for Neuroinflammation and Cardiometabolic Research, Georgia State University, Atlanta, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Isabelle Décosterd
8Pain center, Department of Anesthesiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland
12Department of Fundamental Neurosciences, Faculty of Biology and Medicine (FBM), University of Lausanne, Lausanne, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean-Yves Chatton
8Pain center, Department of Anesthesiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W. Scott Young
13Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ron Stoop
4Center for Psychiatric Neurosciences, Hôpital de Cery, Lausanne University Hospital (CHUV), Lausanne, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pierrick Poisbeau
1Centre National de la Recherche Scientifique and University of Strasbourg, UPR3212 Institute of Cellular and Integrative Neurosciences, Strasbourg, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Valery Grinevich
3Department of Neuropeptide Research for Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexandre Charlet
1Centre National de la Recherche Scientifique and University of Strasbourg, UPR3212 Institute of Cellular and Integrative Neurosciences, Strasbourg, France
14University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: acharlet@unistra.fr
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

SUMMARY

Oxytocin orchestrates social and emotional behaviors through modulation of neural circuits in brain structures such as the central amygdala (CeA). The long-standing dogma is that oxytocin signaling in the central nervous system occurs exclusively via direct actions on neurons. However, several findings over the last decades showed that astrocytes actively participate in the modulation of neuronal circuits. Here, we investigate the degree of astrocytes’ involvement in oxytocin functions. Using astrocyte’ specific gain and loss of function approaches, we demonstrate that CeA astrocytes not only directly respond to oxytocin, but are actually necessary for its effects on neuronal circuits and ultimately behavior. Our work identifies astrocytes as a crucial cellular substrate underlying the promotion of a positive emotional state by oxytocin. These results further corroborate that astrocytes are key regulators of neuronal circuits activity by responding to specific neuropeptidergic inputs, and opens up new perspectives to understand how neuromodulators gate brain functions.

Footnotes

  • ↵# Senior author

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted February 26, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Oxytocin Acts on Astrocytes in the Central Amygdala to Promote a Positive Emotional State
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Oxytocin Acts on Astrocytes in the Central Amygdala to Promote a Positive Emotional State
Jérôme Wahis, Damien Kerspern, Ferdinand Althammer, Angel Baudon, Stéphanie Goyon, Daisuke Hagiwara, Arthur Lefèvre, Benjamin Boury-Jamot, Benjamin Bellanger, Marios Abatis, Miriam Silva da Gouveia, Diego Benusiglio, Marina Eliava, Andrej Rozov, Ivan Weinsanto, Hanna Sophie Knobloch-Bollmann, Hong Wang, Marie Pertin, Perrine Inquimbert, Claudia Pitzer, Jan Siemens, Yannick Goumon, Benjamin Boutrel, Pascal Darbon, Christophe Maurice Lamy, Javier E. Stern, Isabelle Décosterd, Jean-Yves Chatton, W. Scott Young, Ron Stoop, Pierrick Poisbeau, Valery Grinevich, Alexandre Charlet
bioRxiv 2020.02.25.963884; doi: https://doi.org/10.1101/2020.02.25.963884
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Oxytocin Acts on Astrocytes in the Central Amygdala to Promote a Positive Emotional State
Jérôme Wahis, Damien Kerspern, Ferdinand Althammer, Angel Baudon, Stéphanie Goyon, Daisuke Hagiwara, Arthur Lefèvre, Benjamin Boury-Jamot, Benjamin Bellanger, Marios Abatis, Miriam Silva da Gouveia, Diego Benusiglio, Marina Eliava, Andrej Rozov, Ivan Weinsanto, Hanna Sophie Knobloch-Bollmann, Hong Wang, Marie Pertin, Perrine Inquimbert, Claudia Pitzer, Jan Siemens, Yannick Goumon, Benjamin Boutrel, Pascal Darbon, Christophe Maurice Lamy, Javier E. Stern, Isabelle Décosterd, Jean-Yves Chatton, W. Scott Young, Ron Stoop, Pierrick Poisbeau, Valery Grinevich, Alexandre Charlet
bioRxiv 2020.02.25.963884; doi: https://doi.org/10.1101/2020.02.25.963884

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4397)
  • Biochemistry (9632)
  • Bioengineering (7123)
  • Bioinformatics (24940)
  • Biophysics (12671)
  • Cancer Biology (9997)
  • Cell Biology (14405)
  • Clinical Trials (138)
  • Developmental Biology (7989)
  • Ecology (12148)
  • Epidemiology (2067)
  • Evolutionary Biology (16026)
  • Genetics (10953)
  • Genomics (14778)
  • Immunology (9907)
  • Microbiology (23739)
  • Molecular Biology (9508)
  • Neuroscience (51055)
  • Paleontology (370)
  • Pathology (1545)
  • Pharmacology and Toxicology (2693)
  • Physiology (4038)
  • Plant Biology (8696)
  • Scientific Communication and Education (1512)
  • Synthetic Biology (2404)
  • Systems Biology (6459)
  • Zoology (1350)