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General anaesthesia disrupts complex cortical dynamics in response to intracranial electrical stimulation in rats

A. Arena, R. Comolatti, S. Thon, A.G. Casali, J.F. Storm
doi: https://doi.org/10.1101/2020.02.25.964056
A. Arena
1Department of Molecular Medicine, University of Oslo, Oslo, Norway
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  • For correspondence: alessandro.arena@medisin.uio.no j.f.storm@medisin.uio.no
R. Comolatti
2Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil
3Department of Biomedical and Clinical Sciences “L. Sacco”, University of Milan, Milan, Italy
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S. Thon
1Department of Molecular Medicine, University of Oslo, Oslo, Norway
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A.G. Casali
2Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil
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J.F. Storm
1Department of Molecular Medicine, University of Oslo, Oslo, Norway
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  • For correspondence: alessandro.arena@medisin.uio.no j.f.storm@medisin.uio.no
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ABSTRACT

The capacity of the human brain to sustain complex dynamics consistently drops when consciousness fades. Several recent studies in humans found a remarkable reduction of the complexity of cortical responses to local stimulation during dreamless sleep, general anaesthesia, and coma. So far, this perturbational complexity has never been estimated in non-human animals in vivo. Here, we quantify the complexity of electroencephalographic responses to intracranial electrical stimulation in rats, comparing wakefulness to propofol, sevoflurane, and ketamine anaesthesia. We confirm the changes previously observed in humans: from highly complex evoked activity during wakefulness, to simpler responses, suppression of high frequencies, and reduced phase-locking with propofol and sevoflurane. We then deepen our mechanistic understanding by analyzing functional connectivity, and by showing how these parameters dissociate with ketamine, and depend on intensity and site of stimulation. This approach opens the way for further direct investigations of the mechanisms underlying brain complexity and consciousness.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 26, 2020.
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General anaesthesia disrupts complex cortical dynamics in response to intracranial electrical stimulation in rats
A. Arena, R. Comolatti, S. Thon, A.G. Casali, J.F. Storm
bioRxiv 2020.02.25.964056; doi: https://doi.org/10.1101/2020.02.25.964056
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General anaesthesia disrupts complex cortical dynamics in response to intracranial electrical stimulation in rats
A. Arena, R. Comolatti, S. Thon, A.G. Casali, J.F. Storm
bioRxiv 2020.02.25.964056; doi: https://doi.org/10.1101/2020.02.25.964056

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