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Evidence for modulation of EEG microstate sequence by vigilance level

Marina Krylova, Sarah Alizadeh, Igor Izyurov, Vanessa Teckentrup, Catie Chang, Johan van der Meer, Michael Erb, Nils Kroemer, Thomas Koenig, Martin Walter, Hamidreza Jamalabadi
doi: https://doi.org/10.1101/2020.02.26.966150
Marina Krylova
1Department of Psychiatry and Psychotherapy, Division for Translational Psychiatry, University of Tübingen, Tübingen, Germany
9Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
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Sarah Alizadeh
1Department of Psychiatry and Psychotherapy, Division for Translational Psychiatry, University of Tübingen, Tübingen, Germany
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Igor Izyurov
1Department of Psychiatry and Psychotherapy, Division for Translational Psychiatry, University of Tübingen, Tübingen, Germany
9Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
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Vanessa Teckentrup
1Department of Psychiatry and Psychotherapy, Division for Translational Psychiatry, University of Tübingen, Tübingen, Germany
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Catie Chang
2Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, USA
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Johan van der Meer
5QIMR Berghofer Medial Research Institute, Brisbane, Australia
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Michael Erb
6Division of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany
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Nils Kroemer
1Department of Psychiatry and Psychotherapy, Division for Translational Psychiatry, University of Tübingen, Tübingen, Germany
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Thomas Koenig
8Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland
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Martin Walter
1Department of Psychiatry and Psychotherapy, Division for Translational Psychiatry, University of Tübingen, Tübingen, Germany
3Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany
4Leibniz Institute for Neurobiology, Magdeburg, Germany
7Max Planck Institute for biological cybernetics, Tübingen, Germany
9Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
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  • For correspondence: Martin.Walter@med.uni-jena.de hamidreza.jamalabadi@uni-tuebingen.de
Hamidreza Jamalabadi
1Department of Psychiatry and Psychotherapy, Division for Translational Psychiatry, University of Tübingen, Tübingen, Germany
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  • For correspondence: Martin.Walter@med.uni-jena.de hamidreza.jamalabadi@uni-tuebingen.de
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Abstract

The momentary global functional state of the brain is reflected in its electric field configuration and cluster analytical approaches have consistently shown four configurations, referred to as EEG microstate classes A to D. Changes in microstate parameters are associated with a number of neuropsychiatric disorders, task performance, and mental state establishing their relevance for cognition. However, the common practice to use eye-closed resting state data to assess the temporal dynamics of microstate parameters might induce systematic confounds related to vigilance levels. Here, we studied the dynamics of microstate parameters in two independent data sets and showed that the parameters of microstates are strongly associated with vigilance level assessed both by EEG power analysis and fMRI global signal. We found that the duration and contribution of microstate class C, as well as transition probabilities towards microstate class C were positively associated with vigilance, whereas the sign was reversed for microstate classes A and B. Furthermore, in looking for the origins of the correspondence between microstates and vigilance level, we found Granger-causal effects of vigilance levels on microstate sequence parameters. Collectively, our findings suggest that duration and occurrence of microstates have a different origin and possibly reflect different physiological processes. Finally, our findings indicate the need for taking vigilance levels into consideration in resting-sate EEG investigations.

Footnotes

  • Highlights

    • EEG microstate parameters are strongly related to vigilance levels and can predict them

    • We find that vigilance Granger-causes changes in parameters of microstates

    • Duration and occurrence of EEG microstates are differentially modulated by vigilance level

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 27, 2020.
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Evidence for modulation of EEG microstate sequence by vigilance level
Marina Krylova, Sarah Alizadeh, Igor Izyurov, Vanessa Teckentrup, Catie Chang, Johan van der Meer, Michael Erb, Nils Kroemer, Thomas Koenig, Martin Walter, Hamidreza Jamalabadi
bioRxiv 2020.02.26.966150; doi: https://doi.org/10.1101/2020.02.26.966150
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Evidence for modulation of EEG microstate sequence by vigilance level
Marina Krylova, Sarah Alizadeh, Igor Izyurov, Vanessa Teckentrup, Catie Chang, Johan van der Meer, Michael Erb, Nils Kroemer, Thomas Koenig, Martin Walter, Hamidreza Jamalabadi
bioRxiv 2020.02.26.966150; doi: https://doi.org/10.1101/2020.02.26.966150

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