Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Designing membrane-reshaping nanostructures through artificial evolution

View ORCID ProfileJoel C. Forster, View ORCID ProfileJohannes Krausser, View ORCID ProfileManish R. Vuyyuru, View ORCID ProfileBuzz Baum, View ORCID ProfileAnđela Šarić
doi: https://doi.org/10.1101/2020.02.27.968149
Joel C. Forster
1Institute for the Physics of Living Systems, University College London, Gower Street, London, WC1E 6BT, United Kingdom
2MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Joel C. Forster
Johannes Krausser
1Institute for the Physics of Living Systems, University College London, Gower Street, London, WC1E 6BT, United Kingdom
2MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Johannes Krausser
Manish R. Vuyyuru
1Institute for the Physics of Living Systems, University College London, Gower Street, London, WC1E 6BT, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Manish R. Vuyyuru
Buzz Baum
1Institute for the Physics of Living Systems, University College London, Gower Street, London, WC1E 6BT, United Kingdom
2MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Buzz Baum
Anđela Šarić
1Institute for the Physics of Living Systems, University College London, Gower Street, London, WC1E 6BT, United Kingdom
2MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Anđela Šarić
  • For correspondence: a.saric@ucl.ac.uk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

In this paper we combine the rules of natural evolution with molecular dynamics simulations to design a nanostructure with a desired function. We apply this scheme to the case of a ligand-covered nanoparticle and evolve ligand patterns that promote efficient cell uptake. Surprisingly, we find that in the regime of low ligand number the fittest structures are characterised by ligands arranged into long one-dimensional chains that pattern the surface of the particle. We show that these chains of ligands provide particles with high rotational freedom and they lower the free energy barrier for membrane crossing. This demonstrates the efficacy of artificial evolution to identify non-intuitive design rules and reveals a new principle of design that can be used to inform artificial nanoparticle construction and the search for inhibitors of viral entry.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted February 28, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Designing membrane-reshaping nanostructures through artificial evolution
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Designing membrane-reshaping nanostructures through artificial evolution
Joel C. Forster, Johannes Krausser, Manish R. Vuyyuru, Buzz Baum, Anđela Šarić
bioRxiv 2020.02.27.968149; doi: https://doi.org/10.1101/2020.02.27.968149
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Designing membrane-reshaping nanostructures through artificial evolution
Joel C. Forster, Johannes Krausser, Manish R. Vuyyuru, Buzz Baum, Anđela Šarić
bioRxiv 2020.02.27.968149; doi: https://doi.org/10.1101/2020.02.27.968149

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Biophysics
Subject Areas
All Articles
  • Animal Behavior and Cognition (3686)
  • Biochemistry (7774)
  • Bioengineering (5668)
  • Bioinformatics (21244)
  • Biophysics (10563)
  • Cancer Biology (8160)
  • Cell Biology (11909)
  • Clinical Trials (138)
  • Developmental Biology (6738)
  • Ecology (10388)
  • Epidemiology (2065)
  • Evolutionary Biology (13843)
  • Genetics (9694)
  • Genomics (13056)
  • Immunology (8123)
  • Microbiology (19956)
  • Molecular Biology (7832)
  • Neuroscience (42971)
  • Paleontology (318)
  • Pathology (1276)
  • Pharmacology and Toxicology (2256)
  • Physiology (3350)
  • Plant Biology (7208)
  • Scientific Communication and Education (1309)
  • Synthetic Biology (1999)
  • Systems Biology (5528)
  • Zoology (1126)