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More than a feeling: central amygdala mediates social transfer of information about proximity of danger

View ORCID ProfileK. Andraka, View ORCID ProfileK. Kondrakiewicz, K. Rojek-Sito, K. Ziegart-Sadowska, K. Meyza, T. Nikolaev, A. Hamed, M. Kursa, M. Wójcik, K. Danielewski, M. Wiatrowska, E. Kublik, M. Bekisz, T. Lebitko, D. Duque, T. Jaworski, H. Madej, W. Konopka, P. M. Boguszewski, View ORCID ProfileE. Knapska
doi: https://doi.org/10.1101/2020.02.28.969113
K. Andraka
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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K. Kondrakiewicz
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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K. Rojek-Sito
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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K. Ziegart-Sadowska
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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K. Meyza
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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T. Nikolaev
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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A. Hamed
2Laboratory of Spatial Memory, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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M. Kursa
3Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, Poland
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M. Wójcik
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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K. Danielewski
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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M. Wiatrowska
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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E. Kublik
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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M. Bekisz
4Laboratory of Neurobiology of Vision, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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T. Lebitko
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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D. Duque
5Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
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T. Jaworski
6Laboratory of Animals Models, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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H. Madej
6Laboratory of Animals Models, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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W. Konopka
6Laboratory of Animals Models, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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P. M. Boguszewski
6Laboratory of Animals Models, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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E. Knapska
1Laboratory of Emotions Neurobiology, BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences Warsaw, Poland
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  • ORCID record for E. Knapska
  • For correspondence: e.knapska@nencki.edu.pl
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Abstract

To survive, an animal must adequately respond to challenges presented by the environment. Social animals can learn about danger from fear of conspecifics which allows them to avoid predation and other threats without costly, first-hand experience. However, it remains unclear as to whether animals can transmit specific information that helps an individual avoid harm or whether the transmitted social signals simply increase vigilance in a non-specific manner. Here we demonstrate that animals can select appropriate defensive strategies in a novel environment depending on cues from the conspecific and, using opsins targeted to behaviorally activated neurons, identify distinct neuronal circuits in the central amygdala (CeA) that are crucial for choosing a context-appropriate reaction. The identified circuits differ in molecular markers and patterns of connectivity. Thus, we show that social signals carry explicit information about proximity of danger, necessary for choosing a context-appropriate reaction, and that the choosing process is mediated by the CeA circuits.

Footnotes

  • Funding information & acknowledgements were added.

  • https://drive.google.com/a/nencki.edu.pl/file/d/1wPkRrfwu5t6JQi9bOzM-O9r3GYHmSRyV/view?usp=sharing

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 06, 2020.
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More than a feeling: central amygdala mediates social transfer of information about proximity of danger
K. Andraka, K. Kondrakiewicz, K. Rojek-Sito, K. Ziegart-Sadowska, K. Meyza, T. Nikolaev, A. Hamed, M. Kursa, M. Wójcik, K. Danielewski, M. Wiatrowska, E. Kublik, M. Bekisz, T. Lebitko, D. Duque, T. Jaworski, H. Madej, W. Konopka, P. M. Boguszewski, E. Knapska
bioRxiv 2020.02.28.969113; doi: https://doi.org/10.1101/2020.02.28.969113
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More than a feeling: central amygdala mediates social transfer of information about proximity of danger
K. Andraka, K. Kondrakiewicz, K. Rojek-Sito, K. Ziegart-Sadowska, K. Meyza, T. Nikolaev, A. Hamed, M. Kursa, M. Wójcik, K. Danielewski, M. Wiatrowska, E. Kublik, M. Bekisz, T. Lebitko, D. Duque, T. Jaworski, H. Madej, W. Konopka, P. M. Boguszewski, E. Knapska
bioRxiv 2020.02.28.969113; doi: https://doi.org/10.1101/2020.02.28.969113

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