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Controlled neighbor exchanges drive glassy behavior, intermittency and cell streaming in epithelial tissues

View ORCID ProfileAmit Das, Srikanth Sastry, Dapeng Bi
doi: https://doi.org/10.1101/2020.02.28.970541
Amit Das
1Department of Physics, Northeastern University, MA 02115, USA
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Srikanth Sastry
2Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur Campus, Bangalore 560064, India
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Dapeng Bi
1Department of Physics, Northeastern University, MA 02115, USA
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  • For correspondence: d.bi@northeastern.edu
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Abstract

Cell neighbor exchanges are integral to tissue rearrangements in biology, including development and repair. Often these processes occur via topological T1 transitions analogous to those observed in foams, grains and colloids. However, in contrast to in non-living materials the T1 transitions in biological tissues are rate-limited and cannot occur instantaneously due to the finite time required to remodel complex structures at cell-cell junctions. Here we study how this rate-limiting process affects the mechanics and collective behavior of cells in a tissue by introducing this important biological constraint in a theoretical vertex-based model as an intrinsic single-cell property. We report in the absence of this time constraint, the tissue undergoes a motility-driven glass transition characterized by a sharp increase in the intermittency of cell-cell rearrangements. Remarkably, this glass transition disappears as T1 transitions are temporally limited. As a unique consequence of limited rearrangements, we also find that the tissue develops spaitally correlated streams of fast and slow cells, in which the fast cells organize into stream-like patterns with leader-follower interactions, and maintain optimally stable cell-cell contacts. The predictions of this work is compared with existing in-vivo experiments in Drosophila pupal development.

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Posted February 28, 2020.
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Controlled neighbor exchanges drive glassy behavior, intermittency and cell streaming in epithelial tissues
Amit Das, Srikanth Sastry, Dapeng Bi
bioRxiv 2020.02.28.970541; doi: https://doi.org/10.1101/2020.02.28.970541
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Controlled neighbor exchanges drive glassy behavior, intermittency and cell streaming in epithelial tissues
Amit Das, Srikanth Sastry, Dapeng Bi
bioRxiv 2020.02.28.970541; doi: https://doi.org/10.1101/2020.02.28.970541

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