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Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2

Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Michael Endres, Adam Godzik, Karolina Michalska, Andrzej Joachimiak
doi: https://doi.org/10.1101/2020.03.02.968388
Youngchang Kim
1Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60667, USA
2Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA
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Robert Jedrzejczak
1Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60667, USA
2Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA
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Natalia I. Maltseva
1Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60667, USA
2Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA
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Michael Endres
2Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA
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Adam Godzik
3Biomedical Sciences, University of California Riverside, Riverside, CA
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Karolina Michalska
1Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60667, USA
2Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA
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Andrzej Joachimiak
1Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60667, USA
2Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA
4Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, 60367, USA
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  • For correspondence: andrzejj@anl.gov
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ABSTRACT

Severe Acute Respiratory Syndrome Coronavirus 2 is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS- and MERS-CoVs the detailed information about SARS-CoV-2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies and antivirals. We applied high-throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS-CoV-2 proteins and structures. Here we report the high-resolution crystal structure of endoribonuclease Nsp15/NendoU from SARS-CoV-2 – a virus causing current world-wide epidemics. We compare this structure with previously reported models of Nsp15 from SARS and MERS coronaviruses.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted March 03, 2020.
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Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2
Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Michael Endres, Adam Godzik, Karolina Michalska, Andrzej Joachimiak
bioRxiv 2020.03.02.968388; doi: https://doi.org/10.1101/2020.03.02.968388
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Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2
Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Michael Endres, Adam Godzik, Karolina Michalska, Andrzej Joachimiak
bioRxiv 2020.03.02.968388; doi: https://doi.org/10.1101/2020.03.02.968388

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