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Cell-type specific outcome representation in primary motor cortex

Maria Lavzin, Shahar Levy, Hadas Benisty, Uri Dubin, Zohar Brosh, Fadi Aeed, Brett D. Mensh, Yitzhak Schiller, Ron Meir, Omri Barak, Ronen Talmon, Adam W. Hantman, Jackie Schiller
doi: https://doi.org/10.1101/2020.03.03.971077
Maria Lavzin
1Department of Physiology, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel
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Shahar Levy
1Department of Physiology, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel
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Hadas Benisty
2Viterbi Faculty of Electrical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel
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Uri Dubin
1Department of Physiology, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel
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Zohar Brosh
1Department of Physiology, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel
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Fadi Aeed
1Department of Physiology, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel
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Brett D. Mensh
3Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
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Yitzhak Schiller
1Department of Physiology, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel
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Ron Meir
2Viterbi Faculty of Electrical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel
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Omri Barak
1Department of Physiology, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel
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Ronen Talmon
2Viterbi Faculty of Electrical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel
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Adam W. Hantman
3Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
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  • For correspondence: jackie@technion.ac.il hantmana@janelia.hhmi.org
Jackie Schiller
1Department of Physiology, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel
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  • For correspondence: jackie@technion.ac.il hantmana@janelia.hhmi.org
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Abstract

Adaptive movements are critical to animal survival. To guide future actions, the brain monitors different outcomes, including achievement of movement and appetitive goals. The nature of outcome signals and their neuronal and network realization in motor cortex (M1), which commands the performance of skilled movements, is largely unknown. Using a dexterity task, calcium imaging, optogenetic perturbations, and behavioral manipulations, we studied outcome signals in murine M1. We find two populations of layer 2-3 neurons, “success”- and “failure” related neurons that develop with training and report end-result of trials. In these neurons, prolonged responses were recorded after success or failure trials, independent of reward and kinematics. In contrast, the initial state of layer-5 pyramidal tract neurons contains a memory trace of the previous trial’s outcome. Inter-trial cortical activity was needed to learn new task requirements. These M1 reflective layer-specific performance outcome signals, can support reinforcement motor learning of skilled behavior.

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Posted March 04, 2020.
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Cell-type specific outcome representation in primary motor cortex
Maria Lavzin, Shahar Levy, Hadas Benisty, Uri Dubin, Zohar Brosh, Fadi Aeed, Brett D. Mensh, Yitzhak Schiller, Ron Meir, Omri Barak, Ronen Talmon, Adam W. Hantman, Jackie Schiller
bioRxiv 2020.03.03.971077; doi: https://doi.org/10.1101/2020.03.03.971077
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Cell-type specific outcome representation in primary motor cortex
Maria Lavzin, Shahar Levy, Hadas Benisty, Uri Dubin, Zohar Brosh, Fadi Aeed, Brett D. Mensh, Yitzhak Schiller, Ron Meir, Omri Barak, Ronen Talmon, Adam W. Hantman, Jackie Schiller
bioRxiv 2020.03.03.971077; doi: https://doi.org/10.1101/2020.03.03.971077

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