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Superabsorbent crosslinked bacterial cellulose biomaterials for chronic wound dressings

Daria Ciecholewska-Juśko, Anna Żywicka, Adam Junka, Radosław Drozd, Peter Sobolewski, Paweł Migdał, Urszula Kowalska, Monika Toporkiewicz, View ORCID ProfileKarol Fijałkowski
doi: https://doi.org/10.1101/2020.03.04.975003
Daria Ciecholewska-Juśko
aDepartment of Microbiology and Biotechnology, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology, Szczecin, Piastów 45, 70-311 Szczecin, Poland
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Anna Żywicka
aDepartment of Microbiology and Biotechnology, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology, Szczecin, Piastów 45, 70-311 Szczecin, Poland
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Adam Junka
bDepartment of Pharmaceutical Microbiology and Parasitology, Wrocław Medical University, Borowska 211A, 50-556 Wrocław, Poland
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Radosław Drozd
aDepartment of Microbiology and Biotechnology, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology, Szczecin, Piastów 45, 70-311 Szczecin, Poland
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Peter Sobolewski
cDepartment of Polymer and Biomaterials Science, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology, Szczecin, Piastów 45, 70-311 Szczecin, Poland
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Paweł Migdał
dDepartment of Environment, Hygiene and Animal Welfare, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Chełmońskiego 38C, 51-630 Wrocław, Poland
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Urszula Kowalska
eCentre of Bioimmobilization and Innovative Packaging Materials, West Pomeranian University of Technology, Szczecin, Janickiego 35, 71-270 Szczecin, Poland
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Monika Toporkiewicz
fLaboratory of Confocal Microscopy, Łukasiewicz Research Network - PORT Polish Center for Technology Development, Stabłowicka 147, 54-066 Wrocław, Poland
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Karol Fijałkowski
aDepartment of Microbiology and Biotechnology, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology, Szczecin, Piastów 45, 70-311 Szczecin, Poland
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  • ORCID record for Karol Fijałkowski
  • For correspondence: karol.fijalkowski@zut.edu.pl
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Abstract

In this work, we present novel ex situ modification of bacterial cellulose (BC) polymer, that significantly improves its ability to absorb water after drying. The method involves a single inexpensive and easy-to-perform process of BC crosslinking, using citric acid along with catalysts, such as disodium phosphate, sodium bicarbonate, ammonium bicarbonate or their mixtures. In particular, the mixture of disodium phosphate and sodium bicarbonate was the most promising, yielding significantly greater water capacity (over 5 times higher as compared to the unmodified BC) and slower water release (over 6 times as compared to the unmodified BC). Further, our optimized crosslinked BC had over 1.5x higher water capacity than modern commercial dressings dedicated to highly exuding wounds, while exhibiting no cytotoxic effects against fibroblast cell line L929 in vitro. Therefore, our novel BC biomaterial may find application in super-absorbent dressings, designed for chronic wounds with imbalanced moisture level.

Competing Interest Statement

The authors have declared no competing interest.

  • Abbreviations

    BC
    bacterial cellulose
    CAT
    catalyst
    CA
    citric acid
    M1
    modification with disodium phosphate as a catalyst (CAT)
    M2
    modification with sodium bicarbonate as a CAT
    M3
    modification with mixture of disodium phosphate and sodium bicarbonate in the ratio 1:1 as a CAT
    M4
    modification with ammonium bicarbonate as a CAT
    M5
    modification with disodium phosphate and ammonium bicarbonate in the ratio 1:1 as a CAT
    M6
    modification with sodium bicarbonate and ammonium bicarbonate in the ratio 1:1 as a CAT
    M7
    modification with sodium hypophosphite as a CAT
    SHP
    sodium hypophosphite
    SR
    swelling ratio
    WHC
    water holding capacity
    WPG
    weight percent gain.
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    Posted June 27, 2020.
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    Superabsorbent crosslinked bacterial cellulose biomaterials for chronic wound dressings
    Daria Ciecholewska-Juśko, Anna Żywicka, Adam Junka, Radosław Drozd, Peter Sobolewski, Paweł Migdał, Urszula Kowalska, Monika Toporkiewicz, Karol Fijałkowski
    bioRxiv 2020.03.04.975003; doi: https://doi.org/10.1101/2020.03.04.975003
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    Superabsorbent crosslinked bacterial cellulose biomaterials for chronic wound dressings
    Daria Ciecholewska-Juśko, Anna Żywicka, Adam Junka, Radosław Drozd, Peter Sobolewski, Paweł Migdał, Urszula Kowalska, Monika Toporkiewicz, Karol Fijałkowski
    bioRxiv 2020.03.04.975003; doi: https://doi.org/10.1101/2020.03.04.975003

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