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In silico study of the spike protein from SARS-CoV-2 interaction with ACE2: similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism
View ORCID ProfileHoucemeddine Othman, Zied Bouslama, View ORCID ProfileJean-Tristan Brandenburg, Jorge da Rocha, View ORCID ProfileYosr Hamdi, View ORCID ProfileKais Ghedira, Najet-Srairi Abid, View ORCID ProfileScott Hazelhurst
doi: https://doi.org/10.1101/2020.03.04.976027
Houcemeddine Othman
1Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Zied Bouslama
2Laboratory of veterinary epidemiology and microbiology LR16IPT03. Institut Pasteur of Tunis. University of Tunis El Manar, Tunis, Tunisia
Jean-Tristan Brandenburg
1Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Jorge da Rocha
1Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Yosr Hamdi
3Laboratory of Biomedical Genomics and Oncogenetics, LR16IPT05, Pasteur Institute of Tunis, University of Tunis El Manar, Tunis, Tunisia
Kais Ghedira
4Laboratory of Bioinformatics, Biomathematics and Biostatistics - LR16IPT09, Pasteur Institute of Tunis, University Tunis El Manar, Tunis, Tunisia
Najet-Srairi Abid
5Université de Tunis El Manar, Institut Pasteur de Tunis, LR11IPT08 Venins et Biomolécules Thérapeutiques, 1002, Tunis, Tunisia
Scott Hazelhurst
1Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
6School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, South Africa
Posted March 07, 2020.
In silico study of the spike protein from SARS-CoV-2 interaction with ACE2: similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism
Houcemeddine Othman, Zied Bouslama, Jean-Tristan Brandenburg, Jorge da Rocha, Yosr Hamdi, Kais Ghedira, Najet-Srairi Abid, Scott Hazelhurst
bioRxiv 2020.03.04.976027; doi: https://doi.org/10.1101/2020.03.04.976027
In silico study of the spike protein from SARS-CoV-2 interaction with ACE2: similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism
Houcemeddine Othman, Zied Bouslama, Jean-Tristan Brandenburg, Jorge da Rocha, Yosr Hamdi, Kais Ghedira, Najet-Srairi Abid, Scott Hazelhurst
bioRxiv 2020.03.04.976027; doi: https://doi.org/10.1101/2020.03.04.976027
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