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An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication
View ORCID ProfileGuang Song, View ORCID ProfileEmily M. Lee, View ORCID ProfileJianbo Pan, View ORCID ProfileMiao Xu, View ORCID ProfileHee-Sool Rho, View ORCID ProfileYichen Cheng, View ORCID ProfileNadia Whitt, View ORCID ProfileShu Yang, View ORCID ProfileJennifer Kouznetsova, View ORCID ProfileCarleen Klumpp-Thomas, View ORCID ProfileSamuel G. Michael, View ORCID ProfileCedric Moore, View ORCID ProfileKi-Jun Yoon, View ORCID ProfileKimberly M. Christian, View ORCID ProfileAnton Simeonov, View ORCID ProfileWenwei Huang, View ORCID ProfileMenghang Xia, View ORCID ProfileRuili Huang, View ORCID ProfileMadhu Lal-Nag, View ORCID ProfileHengli Tang, View ORCID ProfileWei Zheng, View ORCID ProfileJiang Qian, View ORCID ProfileHongjun Song, View ORCID ProfileGuo-li Ming, View ORCID ProfileHeng Zhu
doi: https://doi.org/10.1101/2020.03.04.976548
Guang Song
1Department of Pharmacology & Molecular Sciences; Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Emily M. Lee
2Department of Biological Science, Florida State University, Tallahassee, FL, 32306, USA
Jianbo Pan
3Department of Ophthalmology; Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Miao Xu
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
5Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China
Hee-Sool Rho
1Department of Pharmacology & Molecular Sciences; Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Yichen Cheng
2Department of Biological Science, Florida State University, Tallahassee, FL, 32306, USA
Nadia Whitt
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Shu Yang
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Jennifer Kouznetsova
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Carleen Klumpp-Thomas
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Samuel G. Michael
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Cedric Moore
1Department of Pharmacology & Molecular Sciences; Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Ki-Jun Yoon
6Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
7Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Kimberly M. Christian
7Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Anton Simeonov
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Wenwei Huang
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Menghang Xia
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Ruili Huang
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Madhu Lal-Nag
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Hengli Tang
2Department of Biological Science, Florida State University, Tallahassee, FL, 32306, USA
Wei Zheng
4National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Jiang Qian
3Department of Ophthalmology; Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Hongjun Song
6Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
7Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
8Department of Cell and Developmental Biology, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
9Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
10The Epigenetics Institute, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Guo-li Ming
6Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
7Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
8Department of Cell and Developmental Biology, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
9Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Heng Zhu
1Department of Pharmacology & Molecular Sciences; Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Posted March 05, 2020.
An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication
Guang Song, Emily M. Lee, Jianbo Pan, Miao Xu, Hee-Sool Rho, Yichen Cheng, Nadia Whitt, Shu Yang, Jennifer Kouznetsova, Carleen Klumpp-Thomas, Samuel G. Michael, Cedric Moore, Ki-Jun Yoon, Kimberly M. Christian, Anton Simeonov, Wenwei Huang, Menghang Xia, Ruili Huang, Madhu Lal-Nag, Hengli Tang, Wei Zheng, Jiang Qian, Hongjun Song, Guo-li Ming, Heng Zhu
bioRxiv 2020.03.04.976548; doi: https://doi.org/10.1101/2020.03.04.976548
An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication
Guang Song, Emily M. Lee, Jianbo Pan, Miao Xu, Hee-Sool Rho, Yichen Cheng, Nadia Whitt, Shu Yang, Jennifer Kouznetsova, Carleen Klumpp-Thomas, Samuel G. Michael, Cedric Moore, Ki-Jun Yoon, Kimberly M. Christian, Anton Simeonov, Wenwei Huang, Menghang Xia, Ruili Huang, Madhu Lal-Nag, Hengli Tang, Wei Zheng, Jiang Qian, Hongjun Song, Guo-li Ming, Heng Zhu
bioRxiv 2020.03.04.976548; doi: https://doi.org/10.1101/2020.03.04.976548
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