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The anti-tubercular activity of simvastatin is mediated by cholesterol-dependent regulation of autophagy via the AMPK-mTORC1-TFEB axis

Natalie Bruiners, Noton K. Dutta, Valentina Guerrini, Hugh Salamon, Ken D. Yamaguchi, Petros C. Karakousis, Maria L. Gennaro
doi: https://doi.org/10.1101/2020.03.04.977579
Natalie Bruiners
1Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, NJ
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Noton K. Dutta
2Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
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Valentina Guerrini
1Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, NJ
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Hugh Salamon
3Knowledge Synthesis Inc., Berkeley, CA
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Ken D. Yamaguchi
3Knowledge Synthesis Inc., Berkeley, CA
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Petros C. Karakousis
2Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
4Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
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Maria L. Gennaro
1Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, NJ
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  • For correspondence: marila.gennaro@rutgers.edu
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Posted March 05, 2020.
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The anti-tubercular activity of simvastatin is mediated by cholesterol-dependent regulation of autophagy via the AMPK-mTORC1-TFEB axis
Natalie Bruiners, Noton K. Dutta, Valentina Guerrini, Hugh Salamon, Ken D. Yamaguchi, Petros C. Karakousis, Maria L. Gennaro
bioRxiv 2020.03.04.977579; doi: https://doi.org/10.1101/2020.03.04.977579
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The anti-tubercular activity of simvastatin is mediated by cholesterol-dependent regulation of autophagy via the AMPK-mTORC1-TFEB axis
Natalie Bruiners, Noton K. Dutta, Valentina Guerrini, Hugh Salamon, Ken D. Yamaguchi, Petros C. Karakousis, Maria L. Gennaro
bioRxiv 2020.03.04.977579; doi: https://doi.org/10.1101/2020.03.04.977579

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