Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design

Wioletta Rut; Katarzyna Groborz; Linlin Zhang; Xinyuanyuan Sun; Mikolaj Zmudzinski; Rolf Hilgenfeld; Marcin Drag

doi:10.1101/2020.03.07.981928

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Substrate specificity profiling of SARS-CoV-2 M^pro protease provides basis for anti-COVID-19 drug design

Wioletta Rut, Katarzyna Groborz, Linlin Zhang, Xinyuanyuan Sun, Mikolaj Zmudzinski, View ORCID ProfileRolf Hilgenfeld, Marcin Drag

doi: https://doi.org/10.1101/2020.03.07.981928

Wioletta Rut

aDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

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For correspondence: [email protected] [email protected]

Katarzyna Groborz

aDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

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Linlin Zhang

bInstitute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Luebeck, Ratzeburger Allee 160, 23562 Luebeck, Germany

cGerman Center for Infection Research (DZIF), Hamburg-Luebeck-Borstel-Riems Site, University of Luebeck, 23562 Luebeck, Germany

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Xinyuanyuan Sun

bInstitute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Luebeck, Ratzeburger Allee 160, 23562 Luebeck, Germany

cGerman Center for Infection Research (DZIF), Hamburg-Luebeck-Borstel-Riems Site, University of Luebeck, 23562 Luebeck, Germany

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Mikolaj Zmudzinski

aDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

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Rolf Hilgenfeld

bInstitute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Luebeck, Ratzeburger Allee 160, 23562 Luebeck, Germany

cGerman Center for Infection Research (DZIF), Hamburg-Luebeck-Borstel-Riems Site, University of Luebeck, 23562 Luebeck, Germany

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ORCID record for Rolf Hilgenfeld

Marcin Drag

aDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

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For correspondence: [email protected] [email protected]

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Posted March 08, 2020.

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Substrate specificity profiling of SARS-CoV-2 M^pro protease provides basis for anti-COVID-19 drug design

Wioletta Rut, Katarzyna Groborz, Linlin Zhang, Xinyuanyuan Sun, Mikolaj Zmudzinski, Rolf Hilgenfeld, Marcin Drag

bioRxiv 2020.03.07.981928; doi: https://doi.org/10.1101/2020.03.07.981928

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Substrate specificity profiling of SARS-CoV-2 M^pro protease provides basis for anti-COVID-19 drug design

Wioletta Rut, Katarzyna Groborz, Linlin Zhang, Xinyuanyuan Sun, Mikolaj Zmudzinski, Rolf Hilgenfeld, Marcin Drag

bioRxiv 2020.03.07.981928; doi: https://doi.org/10.1101/2020.03.07.981928

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