Substrate specificity profiling of SARS-CoV-2 main protease enables design of activity-based probes for patient-sample imaging

Wioletta Rut; Katarzyna Groborz; Linlin Zhang; Xinyuanyuan Sun; Mikolaj Zmudzinski; Bartlomiej Pawlik; Wojciech Młynarski; Rolf Hilgenfeld; Marcin Drag

doi:10.1101/2020.03.07.981928

New Results

Substrate specificity profiling of SARS-CoV-2 main protease enables design of activity-based probes for patient-sample imaging

Wioletta Rut, Katarzyna Groborz, Linlin Zhang, Xinyuanyuan Sun, Mikolaj Zmudzinski, Bartlomiej Pawlik, Wojciech Młynarski, View ORCID ProfileRolf Hilgenfeld, Marcin Drag

doi: https://doi.org/10.1101/2020.03.07.981928

Wioletta Rut

aDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: wioletta.rut@pwr.edu.pl marcin.drag@pwr.edu.pl

Katarzyna Groborz

aDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Linlin Zhang

bInstitute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

cInstitute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

dGerman Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xinyuanyuan Sun

bInstitute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

cInstitute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

dGerman Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mikolaj Zmudzinski

aDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Bartlomiej Pawlik

eDepartment of Pediatrics, Oncology & Hematology, Medical University of Lodz, Sporna 36/50, 91-738 Lodz, Poland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Wojciech Młynarski

eDepartment of Pediatrics, Oncology & Hematology, Medical University of Lodz, Sporna 36/50, 91-738 Lodz, Poland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rolf Hilgenfeld

bInstitute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

dGerman Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Rolf Hilgenfeld

Marcin Drag

aDepartment of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

fSanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: wioletta.rut@pwr.edu.pl marcin.drag@pwr.edu.pl

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Supporting data[supplements/981928_file02.pdf]

View the discussion thread.

PreviousNext

Posted June 08, 2020.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Substrate specificity profiling of SARS-CoV-2 main protease enables design of activity-based probes for patient-sample imaging

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Substrate specificity profiling of SARS-CoV-2 main protease enables design of activity-based probes for patient-sample imaging

Wioletta Rut, Katarzyna Groborz, Linlin Zhang, Xinyuanyuan Sun, Mikolaj Zmudzinski, Bartlomiej Pawlik, Wojciech Młynarski, Rolf Hilgenfeld, Marcin Drag

bioRxiv 2020.03.07.981928; doi: https://doi.org/10.1101/2020.03.07.981928

Share This Article:

Citation Tools

Substrate specificity profiling of SARS-CoV-2 main protease enables design of activity-based probes for patient-sample imaging

Wioletta Rut, Katarzyna Groborz, Linlin Zhang, Xinyuanyuan Sun, Mikolaj Zmudzinski, Bartlomiej Pawlik, Wojciech Młynarski, Rolf Hilgenfeld, Marcin Drag

bioRxiv 2020.03.07.981928; doi: https://doi.org/10.1101/2020.03.07.981928

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Biochemistry

Subject Areas

All Articles

Animal Behavior and Cognition (4847)
Biochemistry (10781)
Bioengineering (8035)
Bioinformatics (27263)
Biophysics (13967)
Cancer Biology (11115)
Cell Biology (16035)
Clinical Trials (138)
Developmental Biology (8773)
Ecology (13270)
Epidemiology (2067)
Evolutionary Biology (17346)
Genetics (11680)
Genomics (15905)
Immunology (11015)
Microbiology (26054)
Molecular Biology (10627)
Neuroscience (56480)
Paleontology (417)
Pathology (1729)
Pharmacology and Toxicology (3000)
Physiology (4539)
Plant Biology (9617)
Scientific Communication and Education (1613)
Synthetic Biology (2685)
Systems Biology (6970)
Zoology (1508)