New Results
Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration
Juliane Obst, Emilie Simon, Maria Martin-Estebane, Elena Pipi, Liana M. Barkwill, View ORCID ProfileIvette Gonzalez-Rivera, Fergus Buchanan, View ORCID ProfileAlan R. Prescott, Dorte Faust, Simon Fox, Janet Brownlees, Debra Taylor, V. Hugh Perry, Hugh Nuthall, Peter J Atkinson, Eric Karran, C Routledge, View ORCID ProfileDiego Gomez-Nicola
doi: https://doi.org/10.1101/2020.03.09.976118
Juliane Obst
1School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Emilie Simon
1School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Maria Martin-Estebane
1School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Elena Pipi
1School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Liana M. Barkwill
1School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Ivette Gonzalez-Rivera
1School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Fergus Buchanan
2Dundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee, United Kingdom
Alan R. Prescott
2Dundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee, United Kingdom
Dorte Faust
3Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK
Simon Fox
3Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK
Janet Brownlees
3Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK
Debra Taylor
3Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK
V. Hugh Perry
1School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Hugh Nuthall
4Eli Lilly Research Centre, Windlesham, Surrey, GU20 6PH, UK
Peter J Atkinson
5Eisai Limited, European Knowledge Centre, Hatfield, Herts, AL10 9SN, UK
Eric Karran
5Eisai Limited, European Knowledge Centre, Hatfield, Herts, AL10 9SN, UK
C Routledge
7Alzheimer’s Research UK, 3 Riverside, Granta Park, Cambridge, CB21 6AD, UK
Diego Gomez-Nicola
1School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Posted March 13, 2020.
Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration
Juliane Obst, Emilie Simon, Maria Martin-Estebane, Elena Pipi, Liana M. Barkwill, Ivette Gonzalez-Rivera, Fergus Buchanan, Alan R. Prescott, Dorte Faust, Simon Fox, Janet Brownlees, Debra Taylor, V. Hugh Perry, Hugh Nuthall, Peter J Atkinson, Eric Karran, C Routledge, Diego Gomez-Nicola
bioRxiv 2020.03.09.976118; doi: https://doi.org/10.1101/2020.03.09.976118
Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration
Juliane Obst, Emilie Simon, Maria Martin-Estebane, Elena Pipi, Liana M. Barkwill, Ivette Gonzalez-Rivera, Fergus Buchanan, Alan R. Prescott, Dorte Faust, Simon Fox, Janet Brownlees, Debra Taylor, V. Hugh Perry, Hugh Nuthall, Peter J Atkinson, Eric Karran, C Routledge, Diego Gomez-Nicola
bioRxiv 2020.03.09.976118; doi: https://doi.org/10.1101/2020.03.09.976118
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