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Rapid growth and fusion of protocells in surface-adhered membrane networks

View ORCID ProfileElif S. Köksal, Susanne Liese, Lin Xue, Ruslan Ryskulov, Lauri Viitala, Andreas Carlson, View ORCID ProfileIrep Gözen
doi: https://doi.org/10.1101/2020.03.10.980417
Elif S. Köksal
1Centre for Molecular Medicine Norway, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway
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  • ORCID record for Elif S. Köksal
Susanne Liese
2Department of Mathematics, Faculty of Mathematics and Natural Sciences, University of Oslo, 0315 Oslo, Norway
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Lin Xue
1Centre for Molecular Medicine Norway, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway
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Ruslan Ryskulov
3Department of Chemistry and Chemical Engineering, Chalmers University of Technology, SE-412 96 Göteborg, Sweden
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Lauri Viitala
3Department of Chemistry and Chemical Engineering, Chalmers University of Technology, SE-412 96 Göteborg, Sweden
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Andreas Carlson
2Department of Mathematics, Faculty of Mathematics and Natural Sciences, University of Oslo, 0315 Oslo, Norway
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Irep Gözen
1Centre for Molecular Medicine Norway, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway
3Department of Chemistry and Chemical Engineering, Chalmers University of Technology, SE-412 96 Göteborg, Sweden
4Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Oslo, 0315 Oslo, Norway
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  • For correspondence: irep@uio.no
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Abstract

Elevated temperatures might have promoted the nucleation, growth and replication of protocells on the early Earth. Recent reports have shown evidence that moderately high temperatures not only permit protocell assembly at the origin of life, but could have actively supported it. Here we show the fast nucleation and growth of vesicular compartments from autonomously formed lipid networks on solid surfaces, induced by a moderate increase in temperature. Branches of the networks, initially consisting of self-assembled interconnected nanotubes, rapidly swell into microcompartments which can spontaneously encapsulate RNA fragments. The increase in temperature further causes fusion of adjacent network-connected compartments, resulting in the redistribution of the RNA. The experimental observations and the mathematical model indicate that the presence of nanotubular interconnections between protocells facilitates the fusion process.

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Posted March 11, 2020.
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Rapid growth and fusion of protocells in surface-adhered membrane networks
Elif S. Köksal, Susanne Liese, Lin Xue, Ruslan Ryskulov, Lauri Viitala, Andreas Carlson, Irep Gözen
bioRxiv 2020.03.10.980417; doi: https://doi.org/10.1101/2020.03.10.980417
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Rapid growth and fusion of protocells in surface-adhered membrane networks
Elif S. Köksal, Susanne Liese, Lin Xue, Ruslan Ryskulov, Lauri Viitala, Andreas Carlson, Irep Gözen
bioRxiv 2020.03.10.980417; doi: https://doi.org/10.1101/2020.03.10.980417

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