Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Value-guided remapping of sensory circuits by lateral orbitofrontal cortex in reversal learning

View ORCID ProfileAbhishek Banerjee, Giuseppe Parente, Jasper Teutsch, Christopher Lewis, Fabian F. Voigt, View ORCID ProfileFritjof Helmchen
doi: https://doi.org/10.1101/2020.03.11.982744
Abhishek Banerjee
1Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zürich
3Biosciences Institute, Newcastle University, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Abhishek Banerjee
  • For correspondence: abhi.banerjee@newcastle.ac.uk helmchen@hifo.uzh.ch
Giuseppe Parente
1Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zürich
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jasper Teutsch
1Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zürich
3Biosciences Institute, Newcastle University, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher Lewis
1Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zürich
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fabian F. Voigt
1Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zürich
2Neuroscience Center Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fritjof Helmchen
1Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zürich
2Neuroscience Center Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Fritjof Helmchen
  • For correspondence: abhi.banerjee@newcastle.ac.uk helmchen@hifo.uzh.ch
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Flexible decision-making is crucial for adaptive behaviour. Such behaviour in mammals largely relies on the frontal cortex, and specifically, the orbitofrontal cortex (OFC). How OFC neurons encode decision variables and instruct sensory areas to guide adaptive behaviour is a key open question. Here we developed a reversal learning task for head-fixed mice together with two-photon calcium imaging to monitor the activity of lateral OFC neuronal populations and investigated their dynamic interaction with primary somatosensory cortex (S1). Mice trained on this task learned to discriminate go/no-go tactile stimuli and adapt their behaviour upon changes in stimulus–reward contingencies (‘rule-switch’). Longitudinal imaging at cellular resolution across weeks during all behavioural phases revealed a distinct engagement of S1 and lateral OFC neurons: S1 neural activity reflected task learning-related responses, while neurons in the lateral OFC saliently and transiently responded to the rule-switch. A subset of OFC neurons conveyed a value prediction error signal via feedback projections to S1, as direct anatomical long-range projections were revealed by retrograde tracing combined with whole-brain light-sheet microscopy. Top-down signals implemented an update of sensory representations and functionally reconfigured a small subpopulation of S1 neurons that were differentially modulated by reward-history. Functional remapping of these neurons crucially depended on top-down inputs, as chemogenetic silencing of lateral OFC neurons disrupted reversal learning and impaired plastic changes in these outcome-sensitive S1 neurons. Our results reveal the presence of long-range cortical interactions between cellular ensembles in higher and lower-order brain areas specifically recruited during context-dependent learning and task-switching. Such interactions crucially implement history-dependent reward-value computations and error heuristics, which, in turn, help guide adaptive behaviour.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted March 12, 2020.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Value-guided remapping of sensory circuits by lateral orbitofrontal cortex in reversal learning
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Value-guided remapping of sensory circuits by lateral orbitofrontal cortex in reversal learning
Abhishek Banerjee, Giuseppe Parente, Jasper Teutsch, Christopher Lewis, Fabian F. Voigt, Fritjof Helmchen
bioRxiv 2020.03.11.982744; doi: https://doi.org/10.1101/2020.03.11.982744
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Value-guided remapping of sensory circuits by lateral orbitofrontal cortex in reversal learning
Abhishek Banerjee, Giuseppe Parente, Jasper Teutsch, Christopher Lewis, Fabian F. Voigt, Fritjof Helmchen
bioRxiv 2020.03.11.982744; doi: https://doi.org/10.1101/2020.03.11.982744

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3602)
  • Biochemistry (7567)
  • Bioengineering (5522)
  • Bioinformatics (20782)
  • Biophysics (10325)
  • Cancer Biology (7978)
  • Cell Biology (11635)
  • Clinical Trials (138)
  • Developmental Biology (6602)
  • Ecology (10200)
  • Epidemiology (2065)
  • Evolutionary Biology (13611)
  • Genetics (9539)
  • Genomics (12844)
  • Immunology (7919)
  • Microbiology (19538)
  • Molecular Biology (7657)
  • Neuroscience (42081)
  • Paleontology (308)
  • Pathology (1257)
  • Pharmacology and Toxicology (2201)
  • Physiology (3267)
  • Plant Biology (7038)
  • Scientific Communication and Education (1294)
  • Synthetic Biology (1951)
  • Systems Biology (5426)
  • Zoology (1116)