The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15

Shutoku Matsuyama; Miyuki Kawase; Naganori Nao; Kazuya Shirato; Makoto Ujike; Wataru Kamitani; Masayuki Shimojima; Shuetsu Fukushi

doi:10.1101/2020.03.11.987016

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The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15

Shutoku Matsuyama, Miyuki Kawase, Naganori Nao, Kazuya Shirato, Makoto Ujike, Wataru Kamitani, Masayuki Shimojima, Shuetsu Fukushi

doi: https://doi.org/10.1101/2020.03.11.987016

Shutoku Matsuyama

1Department of Virology III, National Institute of Infectious Diseases, Tokyo, Japan

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For correspondence: matuyama@nih.go.jp

Miyuki Kawase

1Department of Virology III, National Institute of Infectious Diseases, Tokyo, Japan

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Naganori Nao

1Department of Virology III, National Institute of Infectious Diseases, Tokyo, Japan

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Kazuya Shirato

1Department of Virology III, National Institute of Infectious Diseases, Tokyo, Japan

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Makoto Ujike

2Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan

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Wataru Kamitani

3Department of Infectious Diseases and Host Defense, Gunma University Graduate School of Medicine

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Masayuki Shimojima

4Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan

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Shuetsu Fukushi

4Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan

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The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15

Shutoku Matsuyama, Miyuki Kawase, Naganori Nao, Kazuya Shirato, Makoto Ujike, Wataru Kamitani, Masayuki Shimojima, Shuetsu Fukushi

bioRxiv 2020.03.11.987016; doi: https://doi.org/10.1101/2020.03.11.987016

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The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15

Shutoku Matsuyama, Miyuki Kawase, Naganori Nao, Kazuya Shirato, Makoto Ujike, Wataru Kamitani, Masayuki Shimojima, Shuetsu Fukushi

bioRxiv 2020.03.11.987016; doi: https://doi.org/10.1101/2020.03.11.987016

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