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A human monoclonal antibody blocking SARS-CoV-2 infection

Chunyan Wang, Wentao Li, Dubravka Drabek, Nisreen M.A. Okba, Rien van Haperen, Albert D.M.E. Osterhaus, Frank J.M. van Kuppeveld, Bart L. Haagmans, Frank Grosveld, Berend-Jan Bosch
doi: https://doi.org/10.1101/2020.03.11.987958
Chunyan Wang
aVirology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
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Wentao Li
aVirology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
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Dubravka Drabek
bDepartment of Cell Biology, Erasmus MC, Rotterdam, the Netherlands
cHarbour Antibodies B.V., Rotterdam, Netherlands
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Nisreen M.A. Okba
dDepartment of Molecular and Cell Biology, Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
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Rien van Haperen
bDepartment of Cell Biology, Erasmus MC, Rotterdam, the Netherlands
cHarbour Antibodies B.V., Rotterdam, Netherlands
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Albert D.M.E. Osterhaus
eUniversity of Veterinary Medicine, Hannover, Germany
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Frank J.M. van Kuppeveld
aVirology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
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Bart L. Haagmans
dDepartment of Molecular and Cell Biology, Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
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Frank Grosveld
bDepartment of Cell Biology, Erasmus MC, Rotterdam, the Netherlands
cHarbour Antibodies B.V., Rotterdam, Netherlands
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Berend-Jan Bosch
aVirology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
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  • For correspondence: b.j.bosch@uu.nl
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Abstract

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV). This cross-neutralizing antibody targets a communal epitope on these viruses and offers potential for prevention and treatment of COVID-19.

Footnotes

  • ↵** These authors are joint first authors.

  • ↵$ These authors are joint senior authors.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 12, 2020.
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A human monoclonal antibody blocking SARS-CoV-2 infection
Chunyan Wang, Wentao Li, Dubravka Drabek, Nisreen M.A. Okba, Rien van Haperen, Albert D.M.E. Osterhaus, Frank J.M. van Kuppeveld, Bart L. Haagmans, Frank Grosveld, Berend-Jan Bosch
bioRxiv 2020.03.11.987958; doi: https://doi.org/10.1101/2020.03.11.987958
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A human monoclonal antibody blocking SARS-CoV-2 infection
Chunyan Wang, Wentao Li, Dubravka Drabek, Nisreen M.A. Okba, Rien van Haperen, Albert D.M.E. Osterhaus, Frank J.M. van Kuppeveld, Bart L. Haagmans, Frank Grosveld, Berend-Jan Bosch
bioRxiv 2020.03.11.987958; doi: https://doi.org/10.1101/2020.03.11.987958

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