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Rapidly predicting vancomycin resistance of Enterococcus faecium through MALDI-TOF MS spectrum obtained in real-world clinical microbiology laboratory

Hsin-Yao Wang, Ko-Pei Lu, Chia-Ru Chung, Yi-Ju Tseng, Tzong-Yi Lee, Jorng-Tzong Horng, Tzu-Hao Chang, Min-Hsien Wu, Ting-Wei Lin, Tsui-Ping Liu, Jang-Jih Lu
doi: https://doi.org/10.1101/2020.03.13.990978
Hsin-Yao Wang
1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan
2Ph.D. Program in Biomedical Engineering, Chang Gung University, Taoyuan City, Taiwan
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Ko-Pei Lu
3Graduate Program in Biomedical Information, Yuan-Ze University, Taoyuan City, Taiwan
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Chia-Ru Chung
4Department of Computer Science and Information Engineering, National Central University, Taoyuan City, Taiwan
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Yi-Ju Tseng
1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan
5Department of Information Management, Chang Gung University, Taoyuan City, Taiwan
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Tzong-Yi Lee
1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan
6School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, China
7Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, China
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Jorng-Tzong Horng
1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan
4Department of Computer Science and Information Engineering, National Central University, Taoyuan City, Taiwan
8Department of Bioinformatics and Medical Engineering, Asia University, Taichung City, Taiwan
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Tzu-Hao Chang
9Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei City, Taiwan
10Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei City, Taiwan
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Min-Hsien Wu
11Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City, Taiwan
12Division of Haematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan
13Biosensor Group, Biomedical Engineering Research Center, Chang Gung University, Taoyuan City, Taiwan
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Ting-Wei Lin
1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan
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Tsui-Ping Liu
1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan
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Jang-Jih Lu
1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan
14School of Medicine, Chang Gung University, Taoyuan City, Taiwan
15Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan City, Taiwan
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  • For correspondence: mdhsinyaowang@gmail.com
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Article Information

doi 
https://doi.org/10.1101/2020.03.13.990978
History 
  • March 15, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Hsin-Yao Wang, MD1,2,
  2. Ko-Pei Lu, MS3,
  3. Chia-Ru Chung, MS4,
  4. Yi-Ju Tseng, PhD1,5,
  5. Tzong-Yi Lee, PhD1,6,7,
  6. Jorng-Tzong Horng, PhD1,4,8,
  7. Tzu-Hao Chang, PhD9,10,
  8. Min-Hsien Wu, PhD11,12,13,
  9. Ting-Wei Lin, MD1,
  10. Tsui-Ping Liu, MS1 and
  11. Jang-Jih Lu, MD, PhD1,14,15,*
  1. 1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan
  2. 2Ph.D. Program in Biomedical Engineering, Chang Gung University, Taoyuan City, Taiwan
  3. 3Graduate Program in Biomedical Information, Yuan-Ze University, Taoyuan City, Taiwan
  4. 4Department of Computer Science and Information Engineering, National Central University, Taoyuan City, Taiwan
  5. 5Department of Information Management, Chang Gung University, Taoyuan City, Taiwan
  6. 6School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, China
  7. 7Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, China
  8. 8Department of Bioinformatics and Medical Engineering, Asia University, Taichung City, Taiwan
  9. 9Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei City, Taiwan
  10. 10Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei City, Taiwan
  11. 11Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City, Taiwan
  12. 12Division of Haematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan
  13. 13Biosensor Group, Biomedical Engineering Research Center, Chang Gung University, Taoyuan City, Taiwan
  14. 14School of Medicine, Chang Gung University, Taoyuan City, Taiwan
  15. 15Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan City, Taiwan
  1. ↵*To whom correspondence should be addressed: JJ Lu CORRESPONDENCE
    : Jang-Jih Lu, M.D., Ph.D., Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Department of Medical Biotechnology and Laboratory Science, Chang Gung University, 5 Fu-Shing St. Kweishan, Taoyuan 333, Taiwan mdhsinyaowang{at}gmail.com
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Posted March 15, 2020.
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Rapidly predicting vancomycin resistance of Enterococcus faecium through MALDI-TOF MS spectrum obtained in real-world clinical microbiology laboratory
Hsin-Yao Wang, Ko-Pei Lu, Chia-Ru Chung, Yi-Ju Tseng, Tzong-Yi Lee, Jorng-Tzong Horng, Tzu-Hao Chang, Min-Hsien Wu, Ting-Wei Lin, Tsui-Ping Liu, Jang-Jih Lu
bioRxiv 2020.03.13.990978; doi: https://doi.org/10.1101/2020.03.13.990978
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Rapidly predicting vancomycin resistance of Enterococcus faecium through MALDI-TOF MS spectrum obtained in real-world clinical microbiology laboratory
Hsin-Yao Wang, Ko-Pei Lu, Chia-Ru Chung, Yi-Ju Tseng, Tzong-Yi Lee, Jorng-Tzong Horng, Tzu-Hao Chang, Min-Hsien Wu, Ting-Wei Lin, Tsui-Ping Liu, Jang-Jih Lu
bioRxiv 2020.03.13.990978; doi: https://doi.org/10.1101/2020.03.13.990978

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