Rapidly predicting vancomycin resistance of Enterococcus faecium through MALDI-TOF MS spectrum obtained in real-world clinical microbiology laboratory

Hsin-Yao Wang; Ko-Pei Lu; Chia-Ru Chung; Yi-Ju Tseng; Tzong-Yi Lee; Jorng-Tzong Horng; Tzu-Hao Chang; Min-Hsien Wu; Ting-Wei Lin; Tsui-Ping Liu; Jang-Jih Lu

doi:10.1101/2020.03.13.990978

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Rapidly predicting vancomycin resistance of Enterococcus faecium through MALDI-TOF MS spectrum obtained in real-world clinical microbiology laboratory

Hsin-Yao Wang, Ko-Pei Lu, Chia-Ru Chung, Yi-Ju Tseng, Tzong-Yi Lee, Jorng-Tzong Horng, Tzu-Hao Chang, Min-Hsien Wu, Ting-Wei Lin, Tsui-Ping Liu, Jang-Jih Lu

doi: https://doi.org/10.1101/2020.03.13.990978

Hsin-Yao Wang

1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan

2Ph.D. Program in Biomedical Engineering, Chang Gung University, Taoyuan City, Taiwan

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Ko-Pei Lu

3Graduate Program in Biomedical Information, Yuan-Ze University, Taoyuan City, Taiwan

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Chia-Ru Chung

4Department of Computer Science and Information Engineering, National Central University, Taoyuan City, Taiwan

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Yi-Ju Tseng

1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan

5Department of Information Management, Chang Gung University, Taoyuan City, Taiwan

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Tzong-Yi Lee

1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan

6School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, China

7Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, China

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Jorng-Tzong Horng

1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan

4Department of Computer Science and Information Engineering, National Central University, Taoyuan City, Taiwan

8Department of Bioinformatics and Medical Engineering, Asia University, Taichung City, Taiwan

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Tzu-Hao Chang

9Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei City, Taiwan

10Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei City, Taiwan

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Min-Hsien Wu

11Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City, Taiwan

12Division of Haematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan

13Biosensor Group, Biomedical Engineering Research Center, Chang Gung University, Taoyuan City, Taiwan

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Ting-Wei Lin

1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan

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Tsui-Ping Liu

1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan

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Jang-Jih Lu

1Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan

14School of Medicine, Chang Gung University, Taoyuan City, Taiwan

15Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan City, Taiwan

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For correspondence: mdhsinyaowang@gmail.com

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Rapidly predicting vancomycin resistance of Enterococcus faecium through MALDI-TOF MS spectrum obtained in real-world clinical microbiology laboratory

Hsin-Yao Wang, Ko-Pei Lu, Chia-Ru Chung, Yi-Ju Tseng, Tzong-Yi Lee, Jorng-Tzong Horng, Tzu-Hao Chang, Min-Hsien Wu, Ting-Wei Lin, Tsui-Ping Liu, Jang-Jih Lu

bioRxiv 2020.03.13.990978; doi: https://doi.org/10.1101/2020.03.13.990978

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Rapidly predicting vancomycin resistance of Enterococcus faecium through MALDI-TOF MS spectrum obtained in real-world clinical microbiology laboratory

Hsin-Yao Wang, Ko-Pei Lu, Chia-Ru Chung, Yi-Ju Tseng, Tzong-Yi Lee, Jorng-Tzong Horng, Tzu-Hao Chang, Min-Hsien Wu, Ting-Wei Lin, Tsui-Ping Liu, Jang-Jih Lu

bioRxiv 2020.03.13.990978; doi: https://doi.org/10.1101/2020.03.13.990978

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