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Spectral harmonicity distinguishes two types of ictal phase-amplitude cross frequency couplings in patients candidate to epilepsy surgery

View ORCID ProfileDamián Dellavale, View ORCID ProfileEugenio Urdapilleta, Nuria Cámpora, View ORCID ProfileOsvaldo Matías Velarde, View ORCID ProfileSilvia Kochen, View ORCID ProfileGermán Mato
doi: https://doi.org/10.1101/2020.03.13.991299
Damián Dellavale
aCentro Atómico Bariloche and Instituto Balseiro, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo (UNCUYO), Av. E. Bustillo 9500, R8402AGP San Carlos de Bariloche, Río Negro, Argentina
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  • For correspondence: dellavale@cab.cnea.gov.ar skochen@gmail.com matog@cab.cnea.gov.ar
Eugenio Urdapilleta
aCentro Atómico Bariloche and Instituto Balseiro, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo (UNCUYO), Av. E. Bustillo 9500, R8402AGP San Carlos de Bariloche, Río Negro, Argentina
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Nuria Cámpora
bNeurosciences and Complex Systems Unit (EnyS) - El Cruce “N. Kirchner” Hosp. - UNAJ. Epilepsy Center - “R. Mejía” Hosp. - Faculty of Medicine, UBA - CONICET, Argentina
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Osvaldo Matías Velarde
aCentro Atómico Bariloche and Instituto Balseiro, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo (UNCUYO), Av. E. Bustillo 9500, R8402AGP San Carlos de Bariloche, Río Negro, Argentina
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Silvia Kochen
bNeurosciences and Complex Systems Unit (EnyS) - El Cruce “N. Kirchner” Hosp. - UNAJ. Epilepsy Center - “R. Mejía” Hosp. - Faculty of Medicine, UBA - CONICET, Argentina
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  • For correspondence: dellavale@cab.cnea.gov.ar skochen@gmail.com matog@cab.cnea.gov.ar
Germán Mato
aCentro Atómico Bariloche and Instituto Balseiro, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo (UNCUYO), Av. E. Bustillo 9500, R8402AGP San Carlos de Bariloche, Río Negro, Argentina
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  • For correspondence: dellavale@cab.cnea.gov.ar skochen@gmail.com matog@cab.cnea.gov.ar
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Abstract

Objective Spectral harmonicity of the ictal activity was analyzed regarding two clinically relevant aspects, (1) as a confounding factor producing ‘spurious’ phase-amplitude couplings (PAC) which may lead to wrong conclusions about the underlying ictal mechanisms, and (2) its role in how good PAC is in correspondence to the seizure onset zone (SOZ) classification performed by the epileptologists.

Methods PAC patterns observed in intracerebral electroencephalography (iEEG) recordings were retrospectively studied during seizures of seven patients with pharmacoresistant focal epilepsy. The time locked index (TLI) measure was introduced to quantify the degree of harmonicity between frequency bands associated to the emergence of PAC during epileptic seizures.

Results (1) Harmonic and non harmonic PAC patterns coexist during the seizure dynamics in iEEG recordings with macroelectrodes. (2) Harmonic PAC patterns are an emergent property of the periodic non sinusoidal waveform constituting the epileptiform activity. (3) The TLI metric allows to distinguish the non harmonic PAC pattern, which has been previously associated with the ictal core through the paroxysmal depolarizing shifts mechanism of seizure propagation.

Conclusions Our results suggest that the spectral harmonicity of the ictal activity plays a relevant role in the visual analysis of the iEEG recordings performed by the epileptologists to define the SOZ, and that it should be considered for the proper interpretation of ictal mechanisms.

Significance The proposed harmonicity analysis can be used to improve the delineation of the SOZ by reliably identifying non harmonic PAC patterns emerging from fully recruited cortical and subcortical areas.

Highlights

  • Harmonic and non harmonic phase-amplitude couplings coexist in epileptiform local field potentials.

  • The time locked index quantitatively differentiates harmonic and non harmonic ictal PAC patterns.

  • Spectral harmonicity plays a relevant role in the interpretation of underlying ictal mechanisms.

Footnotes

  • In this version, the main text and the appendix are included in a single pdf file.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 18, 2020.
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Spectral harmonicity distinguishes two types of ictal phase-amplitude cross frequency couplings in patients candidate to epilepsy surgery
Damián Dellavale, Eugenio Urdapilleta, Nuria Cámpora, Osvaldo Matías Velarde, Silvia Kochen, Germán Mato
bioRxiv 2020.03.13.991299; doi: https://doi.org/10.1101/2020.03.13.991299
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Spectral harmonicity distinguishes two types of ictal phase-amplitude cross frequency couplings in patients candidate to epilepsy surgery
Damián Dellavale, Eugenio Urdapilleta, Nuria Cámpora, Osvaldo Matías Velarde, Silvia Kochen, Germán Mato
bioRxiv 2020.03.13.991299; doi: https://doi.org/10.1101/2020.03.13.991299

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