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Morphological and functional variability in central and subcentral motor cortex of the human brain

View ORCID ProfileNicole Eichert, View ORCID ProfileKate E. Watkins, View ORCID ProfileRogier B. Mars, Michael Petrides
doi: https://doi.org/10.1101/2020.03.17.995035
Nicole Eichert
1Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom
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  • For correspondence: nicole.eichert@psy.ox.ac.uk
Kate E. Watkins
2Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, OX2 6GG, Oxford, United Kingdom
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Rogier B. Mars
1Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom
3Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 AJ Nijmegen, The Netherlands
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Michael Petrides
4Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal H3A 2B4, QC, Canada
5Department of Psychology, McGill University, 1205 Dr. Penfield Avenue, Montreal H3A 1B1, QC, Canada
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Abstract

There is a long-established link between anatomy and function in the somatomotor system in the mammalian cerebral cortex. The morphology of the central sulcus is highly predictive of the location of functional activation peaks relating to movement of different effectors in individuals. In contrast, morphological variation in the subcentral region and its relationship to function is, as yet, unknown. Investigating the subcentral region is particularly important in the context of speech, since control of the larynx during human speech production is related to activity in this region. Here, we examined the relationship between morphology in the central and subcentral region and the location of functional activity during movement of the hand, lips, tongue, and larynx at the individual subject level. We provide a systematic description of the sulcal patterns of the subcentral and adjacent opercular cortex, including the inter-individual variability of sulcal morphology. We show that, in the majority of subjects, the anterior subcentral sulcus is not continuous, but consists of two distinct segments. A robust relationship between morphology of the central and subcentral sulcal segments and movement of different effectors was demonstrated. Inter-individual variability of underlying anatomy might thus explain previous inconsistent findings, in particular regarding the ventral larynx area in subcentral cortex. A surface registration based on sulcal labels indicated that such anatomical information can improve the alignment of functional data for group studies.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Manuscript revised

  • https://git.fmrib.ox.ac.uk/neichert/project_variability/-/blob/master/sulci_individual.gif

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted July 29, 2020.
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Morphological and functional variability in central and subcentral motor cortex of the human brain
Nicole Eichert, Kate E. Watkins, Rogier B. Mars, Michael Petrides
bioRxiv 2020.03.17.995035; doi: https://doi.org/10.1101/2020.03.17.995035
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Morphological and functional variability in central and subcentral motor cortex of the human brain
Nicole Eichert, Kate E. Watkins, Rogier B. Mars, Michael Petrides
bioRxiv 2020.03.17.995035; doi: https://doi.org/10.1101/2020.03.17.995035

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