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A role for the cortex in sleep-wake regulation

View ORCID ProfileLukas B. Krone, View ORCID ProfileTomoko Yamagata, View ORCID ProfileCristina Blanco-Duque, View ORCID ProfileMathilde C. C. Guillaumin, View ORCID ProfileMartin C. Kahn, View ORCID ProfileColin J. Akerman, View ORCID ProfileAnna Hoerder-Suabedissen, View ORCID ProfileZoltán Molnár, View ORCID ProfileVladyslav V. Vyazovskiy
doi: https://doi.org/10.1101/2020.03.17.996090
Lukas B. Krone
1Department of Physiology, Anatomy and Genetics, University of Oxford, UK
2Sleep and Circadian Neuroscience Institute, University of Oxford, UK
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Tomoko Yamagata
2Sleep and Circadian Neuroscience Institute, University of Oxford, UK
3Nuffield Department of Clinical Neurosciences, University of Oxford, UK
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Cristina Blanco-Duque
1Department of Physiology, Anatomy and Genetics, University of Oxford, UK
2Sleep and Circadian Neuroscience Institute, University of Oxford, UK
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Mathilde C. C. Guillaumin
2Sleep and Circadian Neuroscience Institute, University of Oxford, UK
3Nuffield Department of Clinical Neurosciences, University of Oxford, UK
4Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zürich, CH
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Martin C. Kahn
1Department of Physiology, Anatomy and Genetics, University of Oxford, UK
2Sleep and Circadian Neuroscience Institute, University of Oxford, UK
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Colin J. Akerman
5Department of Pharmacology, University of Oxford, UK
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Anna Hoerder-Suabedissen
1Department of Physiology, Anatomy and Genetics, University of Oxford, UK
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  • ORCID record for Anna Hoerder-Suabedissen
Zoltán Molnár
1Department of Physiology, Anatomy and Genetics, University of Oxford, UK
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  • For correspondence: vladyslav.vyazovskiy@dpag.ox.ac.uk zoltan.molnar@dpag.ox.ac.uk
Vladyslav V. Vyazovskiy
1Department of Physiology, Anatomy and Genetics, University of Oxford, UK
2Sleep and Circadian Neuroscience Institute, University of Oxford, UK
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  • For correspondence: vladyslav.vyazovskiy@dpag.ox.ac.uk zoltan.molnar@dpag.ox.ac.uk
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Abstract

The cortex and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global control of vigilance states. Here we silenced a subset of cortical layer 5 pyramidal and dentate gyrus granule cells in mice using a cell-specific ablation of the key t-SNARE protein SNAP25. We found a marked increase in wakefulness accompanied by a reduced rebound of EEG slow-wave activity after sleep deprivation. Our data illustrates an important role for the cortex in both global state control and sleep homeostasis.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Following the feedback on the first version of this manuscript, we have now reworded and restructured the main text and made some minor changes to the figures to improve the accessibility for the reader.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted April 18, 2020.
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A role for the cortex in sleep-wake regulation
Lukas B. Krone, Tomoko Yamagata, Cristina Blanco-Duque, Mathilde C. C. Guillaumin, Martin C. Kahn, Colin J. Akerman, Anna Hoerder-Suabedissen, Zoltán Molnár, Vladyslav V. Vyazovskiy
bioRxiv 2020.03.17.996090; doi: https://doi.org/10.1101/2020.03.17.996090
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A role for the cortex in sleep-wake regulation
Lukas B. Krone, Tomoko Yamagata, Cristina Blanco-Duque, Mathilde C. C. Guillaumin, Martin C. Kahn, Colin J. Akerman, Anna Hoerder-Suabedissen, Zoltán Molnár, Vladyslav V. Vyazovskiy
bioRxiv 2020.03.17.996090; doi: https://doi.org/10.1101/2020.03.17.996090

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