Abstract
The cortex and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global control of vigilance states. Here we silenced a subset of cortical layer 5 pyramidal and dentate gyrus granule cells in mice using a cell-specific ablation of the key t-SNARE protein SNAP25. We found a marked increase in wakefulness accompanied by a reduced rebound of EEG slow-wave activity after sleep deprivation. Our data illustrates an important role for the cortex in both global state control and sleep homeostasis.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Following the feedback on the first version of this manuscript, we have now reworded and restructured the main text and made some minor changes to the figures to improve the accessibility for the reader.
