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Profiling microglia from AD donors and non-demented elderly in acute human post-mortem cortical tissue

Astrid M. Alsema, Qiong Jiang, Laura Kracht, Emma Gerrits, Marissa L. Dubbelaar, Anneke Miedema, Nieske Brouwer, Maya Woodbury, Astrid Wachter, Hualin S. Xi, Thomas Möller, Knut P. Biber, Susanne M. Kooistra, Erik W.G.M Boddeke, Bart J.L. Eggen
doi: https://doi.org/10.1101/2020.03.18.995332
Astrid M. Alsema
1Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands
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Qiong Jiang
1Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands
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Laura Kracht
1Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands
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Emma Gerrits
1Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands
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Marissa L. Dubbelaar
1Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands
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Anneke Miedema
1Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands
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Nieske Brouwer
1Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands
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Maya Woodbury
3Foundational Neuroscience Center, AbbVie Inc., Cambridge, Massachusetts, United States of America
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Astrid Wachter
4Neuroscience Discovery, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany
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Hualin S. Xi
3Foundational Neuroscience Center, AbbVie Inc., Cambridge, Massachusetts, United States of America
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Thomas Möller
3Foundational Neuroscience Center, AbbVie Inc., Cambridge, Massachusetts, United States of America
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Knut P. Biber
4Neuroscience Discovery, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany
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Susanne M. Kooistra
1Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands
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Erik W.G.M Boddeke
1Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands
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Bart J.L. Eggen
1Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands
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  • For correspondence: b.j.l.eggen@umcg.nl
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Article Information

doi 
https://doi.org/10.1101/2020.03.18.995332
History 
  • March 19, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Astrid M. Alsema1,#,
  2. Qiong Jiang1,#,
  3. Laura Kracht1,#,
  4. Emma Gerrits1,
  5. Marissa L. Dubbelaar1,
  6. Anneke Miedema1,
  7. Nieske Brouwer1,
  8. Maya Woodbury3,
  9. Astrid Wachter4,
  10. Hualin S. Xi3,
  11. Thomas Möller3,
  12. Knut P. Biber4,
  13. Susanne M. Kooistra1,
  14. Erik W.G.M Boddeke1,a and
  15. Bart J.L. Eggen1,a,*
  1. 1Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands
  2. 3Foundational Neuroscience Center, AbbVie Inc., Cambridge, Massachusetts, United States of America
  3. 4Neuroscience Discovery, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany
  1. ↵*Correspondence: Prof. dr. Bart J.L. Eggen, b.j.l.eggen{at}umcg.nl
  1. ↵# These authors contributed equally to this work.

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Profiling microglia from AD donors and non-demented elderly in acute human post-mortem cortical tissue
Astrid M. Alsema, Qiong Jiang, Laura Kracht, Emma Gerrits, Marissa L. Dubbelaar, Anneke Miedema, Nieske Brouwer, Maya Woodbury, Astrid Wachter, Hualin S. Xi, Thomas Möller, Knut P. Biber, Susanne M. Kooistra, Erik W.G.M Boddeke, Bart J.L. Eggen
bioRxiv 2020.03.18.995332; doi: https://doi.org/10.1101/2020.03.18.995332
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Profiling microglia from AD donors and non-demented elderly in acute human post-mortem cortical tissue
Astrid M. Alsema, Qiong Jiang, Laura Kracht, Emma Gerrits, Marissa L. Dubbelaar, Anneke Miedema, Nieske Brouwer, Maya Woodbury, Astrid Wachter, Hualin S. Xi, Thomas Möller, Knut P. Biber, Susanne M. Kooistra, Erik W.G.M Boddeke, Bart J.L. Eggen
bioRxiv 2020.03.18.995332; doi: https://doi.org/10.1101/2020.03.18.995332

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