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Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase

Minchen Chien, Thomas K. Anderson, Steffen Jockusch, Chuanjuan Tao, Shiv Kumar, Xiaoxu Li, James J. Russo, Robert N. Kirchdoerfer, Jingyue Ju
doi: https://doi.org/10.1101/2020.03.18.997585
Minchen Chien
1Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY 10027
2Departments of Chemical Engineering, Columbia University, New York, NY 10027
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Thomas K. Anderson
3Departments of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706
4Institute of Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706
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Steffen Jockusch
1Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY 10027
5Departments of Chemistry, Columbia University, New York, NY 10027
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Chuanjuan Tao
1Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY 10027
2Departments of Chemical Engineering, Columbia University, New York, NY 10027
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Shiv Kumar
1Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY 10027
2Departments of Chemical Engineering, Columbia University, New York, NY 10027
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Xiaoxu Li
1Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY 10027
2Departments of Chemical Engineering, Columbia University, New York, NY 10027
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James J. Russo
1Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY 10027
2Departments of Chemical Engineering, Columbia University, New York, NY 10027
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Robert N. Kirchdoerfer
3Departments of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706
4Institute of Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706
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  • For correspondence: dj222@columbia.edu rnkirchdoerf@wisc.edu
Jingyue Ju
1Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY 10027
2Departments of Chemical Engineering, Columbia University, New York, NY 10027
6Departments of Pharmacology, Columbia University, New York, NY 10027
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  • For correspondence: dj222@columbia.edu rnkirchdoerf@wisc.edu
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Article Information

doi 
https://doi.org/10.1101/2020.03.18.997585
History 
  • March 20, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Minchen Chien1,2,
  2. Thomas K. Anderson3,4,
  3. Steffen Jockusch1,5,
  4. Chuanjuan Tao1,2,
  5. Shiv Kumar1,2,
  6. Xiaoxu Li1,2,
  7. James J. Russo1,2,
  8. Robert N. Kirchdoerfer3,4,* and
  9. Jingyue Ju1,2,6,*
  1. 1Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY 10027
  2. 2Departments of Chemical Engineering, Columbia University, New York, NY 10027
  3. 3Departments of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706
  4. 4Institute of Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706
  5. 5Departments of Chemistry, Columbia University, New York, NY 10027
  6. 6Departments of Pharmacology, Columbia University, New York, NY 10027
  1. ↵*To whom correspondence should be addressed: dj222{at}columbia.edu (JJ); rnkirchdoerf{at}wisc.edu (RNK)
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Posted March 20, 2020.
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Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase
Minchen Chien, Thomas K. Anderson, Steffen Jockusch, Chuanjuan Tao, Shiv Kumar, Xiaoxu Li, James J. Russo, Robert N. Kirchdoerfer, Jingyue Ju
bioRxiv 2020.03.18.997585; doi: https://doi.org/10.1101/2020.03.18.997585
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Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase
Minchen Chien, Thomas K. Anderson, Steffen Jockusch, Chuanjuan Tao, Shiv Kumar, Xiaoxu Li, James J. Russo, Robert N. Kirchdoerfer, Jingyue Ju
bioRxiv 2020.03.18.997585; doi: https://doi.org/10.1101/2020.03.18.997585

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