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Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

Sangeun Jeon, Meehyun Ko, Jihye Lee, Inhee Choi, Soo Young Byun, Soonju Park, David Shum, Seungtaek Kim
doi: https://doi.org/10.1101/2020.03.20.999730
Sangeun Jeon
1Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam, Korea
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Meehyun Ko
1Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam, Korea
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Jihye Lee
1Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam, Korea
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Inhee Choi
2Medicinal Chemistry, Institut Pasteur Korea, Seongnam, Korea
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Soo Young Byun
3Screening Discovery Platform, Institut Pasteur Korea, Seongnam, Korea
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Soonju Park
3Screening Discovery Platform, Institut Pasteur Korea, Seongnam, Korea
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David Shum
3Screening Discovery Platform, Institut Pasteur Korea, Seongnam, Korea
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Seungtaek Kim
1Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam, Korea
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  • For correspondence: seungtaek.kim@ip-korea.org
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Abstract

COVID-19 is an emerging infectious disease and was recently declared as a pandemic by WHO. Currently, there is no vaccine or therapeutic available for this disease. Drug repositioning represents the only feasible option to address this global challenge and a panel of 49 FDA-approved drugs that have been pre-selected by an assay of SARS-CoV was screened to identify potential antiviral drug candidates against SARS-CoV-2 infection. We found a total of 24 drugs which exhibited antiviral efficacy (0.1 µM < IC50 < 10 µM) against SARS-CoV-2. In particular, two FDA-approved drugs - niclosamide and ciclesonide – were notable in some respects. These drugs will be tested in an appropriate animal model for their antiviral activities. In near future, these already FDA-approved drugs could be further developed following clinical trials in order to provide additional therapeutic options for patients with COVID-19.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted March 23, 2020.
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Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs
Sangeun Jeon, Meehyun Ko, Jihye Lee, Inhee Choi, Soo Young Byun, Soonju Park, David Shum, Seungtaek Kim
bioRxiv 2020.03.20.999730; doi: https://doi.org/10.1101/2020.03.20.999730
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Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs
Sangeun Jeon, Meehyun Ko, Jihye Lee, Inhee Choi, Soo Young Byun, Soonju Park, David Shum, Seungtaek Kim
bioRxiv 2020.03.20.999730; doi: https://doi.org/10.1101/2020.03.20.999730

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