New Results
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
David E. Gordon, View ORCID ProfileGwendolyn M. Jang, View ORCID ProfileMehdi Bouhaddou, View ORCID ProfileJiewei Xu, View ORCID ProfileKirsten Obernier, View ORCID ProfileMatthew J. O’Meara, Jeffrey Z. Guo, View ORCID ProfileDanielle L. Swaney, View ORCID ProfileTia A. Tummino, View ORCID ProfileRuth Huettenhain, View ORCID ProfileRobyn M. Kaake, View ORCID ProfileAlicia L. Richards, View ORCID ProfileBeril Tutuncuoglu, Helene Foussard, View ORCID ProfileJyoti Batra, View ORCID ProfileKelsey Haas, View ORCID ProfileMaya Modak, View ORCID ProfileMinkyu Kim, View ORCID ProfilePaige Haas, View ORCID ProfileBenjamin J. Polacco, View ORCID ProfileHannes Braberg, Jacqueline M. Fabius, View ORCID ProfileManon Eckhardt, View ORCID ProfileMargaret Soucheray, Melanie J. Bennett, View ORCID ProfileMerve Cakir, View ORCID ProfileMichael J. McGregor, View ORCID ProfileQiongyu Li, View ORCID ProfileZun Zar Chi Naing, View ORCID ProfileYuan Zhou, Shiming Peng, View ORCID ProfileIlsa T. Kirby, View ORCID ProfileJames E. Melnyk, View ORCID ProfileJohn S. Chorba, View ORCID ProfileKevin Lou, View ORCID ProfileShizhong A. Dai, View ORCID ProfileWenqi Shen, View ORCID ProfileYing Shi, View ORCID ProfileZiyang Zhang, View ORCID ProfileInigo Barrio-Hernandez, View ORCID ProfileDanish Memon, View ORCID ProfileClaudia Hernandez-Armenta, View ORCID ProfileChristopher J.P. Mathy, View ORCID ProfileTina Perica, View ORCID ProfileKala B. Pilla, View ORCID ProfileSai J. Ganesan, View ORCID ProfileDaniel J. Saltzberg, View ORCID ProfileRakesh Ramachandran, Xi Liu, View ORCID ProfileSara B. Rosenthal, View ORCID ProfileLorenzo Calviello, View ORCID ProfileSrivats Venkataramanan, Jose Liboy-Lugo, View ORCID ProfileYizhu Lin, View ORCID ProfileStephanie A. Wankowicz, View ORCID ProfileMarkus Bohn, Phillip P. Sharp, View ORCID ProfileRaphael Trenker, View ORCID ProfileJanet M. Young, View ORCID ProfileDevin A. Cavero, View ORCID ProfileJoseph Hiatt, View ORCID ProfileTheodore L. Roth, View ORCID ProfileUjjwal Rathore, View ORCID ProfileAdvait Subramanian, Julia Noack, Mathieu Hubert, Ferdinand Roesch, Thomas Vallet, Björn Meyer, View ORCID ProfileKris M. White, View ORCID ProfileLisa Miorin, Oren S. Rosenberg, Kliment A Verba, View ORCID ProfileDavid Agard, Melanie Ott, View ORCID ProfileMichael Emerman, View ORCID ProfileDavide Ruggero, View ORCID ProfileAdolfo García-Sastre, View ORCID ProfileNatalia Jura, View ORCID ProfileMark von Zastrow, View ORCID ProfileJack Taunton, Alan Ashworth, View ORCID ProfileOlivier Schwartz, View ORCID ProfileMarco Vignuzzi, View ORCID ProfileChristophe d’Enfert, View ORCID ProfileShaeri Mukherjee, Matt Jacobson, View ORCID ProfileHarmit S. Malik, View ORCID ProfileDanica G. Fujimori, View ORCID ProfileTrey Ideker, View ORCID ProfileCharles S. Craik, View ORCID ProfileStephen Floor, View ORCID ProfileJames S. Fraser, View ORCID ProfileJohn Gross, View ORCID ProfileAndrej Sali, View ORCID ProfileTanja Kortemme, View ORCID ProfilePedro Beltrao, View ORCID ProfileKevan Shokat, View ORCID ProfileBrian K. Shoichet, View ORCID ProfileNevan J. Krogan
doi: https://doi.org/10.1101/2020.03.22.002386
David E. Gordon
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Gwendolyn M. Jang
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Mehdi Bouhaddou
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Jiewei Xu
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Kirsten Obernier
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Matthew J. O’Meara
5Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA
Jeffrey Z. Guo
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Danielle L. Swaney
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Tia A. Tummino
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
6Department of Pharmaceutical Chemistry, University of California, San Francisco
Ruth Huettenhain
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Robyn M. Kaake
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Alicia L. Richards
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Beril Tutuncuoglu
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Helene Foussard
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Jyoti Batra
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Kelsey Haas
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Maya Modak
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Minkyu Kim
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Paige Haas
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Benjamin J. Polacco
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Hannes Braberg
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Jacqueline M. Fabius
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Manon Eckhardt
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Margaret Soucheray
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Melanie J. Bennett
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Merve Cakir
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Michael J. McGregor
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Qiongyu Li
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Zun Zar Chi Naing
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Yuan Zhou
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Shiming Peng
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
6Department of Pharmaceutical Chemistry, University of California, San Francisco
Ilsa T. Kirby
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
7Howard Hughes Medical Institute
James E. Melnyk
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
7Howard Hughes Medical Institute
John S. Chorba
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
7Howard Hughes Medical Institute
Kevin Lou
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
7Howard Hughes Medical Institute
Shizhong A. Dai
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
7Howard Hughes Medical Institute
Wenqi Shen
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
7Howard Hughes Medical Institute
Ying Shi
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
7Howard Hughes Medical Institute
Ziyang Zhang
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
7Howard Hughes Medical Institute
Inigo Barrio-Hernandez
8European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
Danish Memon
8European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
Claudia Hernandez-Armenta
8European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
Christopher J.P. Mathy
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
10The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
Tina Perica
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
Kala B. Pilla
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
Sai J. Ganesan
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
Daniel J. Saltzberg
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
Rakesh Ramachandran
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
Xi Liu
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
6Department of Pharmaceutical Chemistry, University of California, San Francisco
Sara B. Rosenthal
11Center for Computational Biology and Bioinformatics, Department of Medicine, University of California San Diego
Lorenzo Calviello
12Department of Cell and Tissue Biology, University of California, San Francisco
Srivats Venkataramanan
12Department of Cell and Tissue Biology, University of California, San Francisco
Jose Liboy-Lugo
12Department of Cell and Tissue Biology, University of California, San Francisco
Yizhu Lin
12Department of Cell and Tissue Biology, University of California, San Francisco
Stephanie A. Wankowicz
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
13Biophysics Graduate Program, University of California, San Francisco
9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
Markus Bohn
6Department of Pharmaceutical Chemistry, University of California, San Francisco
Phillip P. Sharp
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Raphael Trenker
14Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, 94158, USA
Janet M. Young
15Division of Basic Sciences, Fred Hutchinson Cancer Research Center
Devin A. Cavero
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
Joseph Hiatt
16Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
Theodore L. Roth
16Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
Ujjwal Rathore
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
Advait Subramanian
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
17George William Hooper Foundation, Department of Microbiology and Immunology, UC San Francisco
Julia Noack
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
17George William Hooper Foundation, Department of Microbiology and Immunology, UC San Francisco
Mathieu Hubert
18Virus and Immunity Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Ferdinand Roesch
19Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France
Thomas Vallet
19Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France
Björn Meyer
19Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France
Kris M. White
20Department for Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY
Lisa Miorin
20Department for Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY
Oren S. Rosenberg
21Department of Medicine, University of California San Francisco, San Francisco, CA, USA
22Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA
23Chan-Zuckerberg Biohub
Kliment A Verba
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
6Department of Pharmaceutical Chemistry, University of California, San Francisco
David Agard
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
24Biochemistry & Biophysics and Quantitative Biosciences Institute UCSF 600 16th St San Francisco, CA 94143
Melanie Ott
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
21Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Michael Emerman
25Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103
Davide Ruggero
26Department of Urology, University of California, San Francisco, San Francisco, CA, USA
27Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Adolfo García-Sastre
20Department for Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY
Natalia Jura
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
14Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Mark von Zastrow
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
14Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, 94158, USA
28University of California San Francisco, Department of Psychiatry, San Francisco, CA, 94158, USA
Jack Taunton
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Alan Ashworth
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
27Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, 94158, USA
Olivier Schwartz
18Virus and Immunity Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Marco Vignuzzi
19Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France
Christophe d’Enfert
29Direction Scientifique, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France
Shaeri Mukherjee
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
17George William Hooper Foundation, Department of Microbiology and Immunology, UC San Francisco
Matt Jacobson
6Department of Pharmaceutical Chemistry, University of California, San Francisco
Harmit S. Malik
15Division of Basic Sciences, Fred Hutchinson Cancer Research Center
Danica G. Fujimori
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
6Department of Pharmaceutical Chemistry, University of California, San Francisco
Trey Ideker
30Division of Genetics, Department of Medicine, University of California San Diego
Charles S. Craik
6Department of Pharmaceutical Chemistry, University of California, San Francisco
27Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, 94158, USA
Stephen Floor
12Department of Cell and Tissue Biology, University of California, San Francisco
27Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, 94158, USA
James S. Fraser
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
John Gross
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
6Department of Pharmaceutical Chemistry, University of California, San Francisco
Andrej Sali
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
6Department of Pharmaceutical Chemistry, University of California, San Francisco
9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
Tanja Kortemme
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
10The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
Pedro Beltrao
8European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
Kevan Shokat
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
7Howard Hughes Medical Institute
Brian K. Shoichet
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
6Department of Pharmaceutical Chemistry, University of California, San Francisco
Nevan J. Krogan
1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
3J. David Gladstone Institutes, San Francisco, CA 94158, USA
4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
Article Information
History
- March 27, 2020.
Article Versions
- Version 1 (March 22, 2020 - 20:07).
- Version 2 (March 23, 2020 - 19:18).
- You are viewing Version 3, the most recent version of this article.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Author Information
- David E. Gordon1,2,3,4,
- Gwendolyn M. Jang1,2,3,4,
- Mehdi Bouhaddou1,2,3,4,
- Jiewei Xu1,2,3,4,
- Kirsten Obernier1,2,3,4,
- Matthew J. O’Meara5,
- Jeffrey Z. Guo1,2,3,4,
- Danielle L. Swaney1,2,3,4,
- Tia A. Tummino1,2,6,
- Ruth Huettenhain1,2,3,4,
- Robyn M. Kaake1,2,3,4,
- Alicia L. Richards1,2,3,4,
- Beril Tutuncuoglu1,2,3,4,
- Helene Foussard1,2,3,4,
- Jyoti Batra1,2,3,4,
- Kelsey Haas1,2,3,4,
- Maya Modak1,2,3,4,
- Minkyu Kim1,2,3,4,
- Paige Haas1,2,3,4,
- Benjamin J. Polacco1,2,3,4,
- Hannes Braberg1,2,3,4,
- Jacqueline M. Fabius1,2,3,4,
- Manon Eckhardt1,2,3,4,
- Margaret Soucheray1,2,3,4,
- Melanie J. Bennett1,2,3,4,
- Merve Cakir1,2,3,4,
- Michael J. McGregor1,2,3,4,
- Qiongyu Li1,2,3,4,
- Zun Zar Chi Naing1,2,3,4,
- Yuan Zhou1,2,3,4,
- Shiming Peng1,2,6,
- Ilsa T. Kirby1,4,7,
- James E. Melnyk1,4,7,
- John S. Chorba1,4,7,
- Kevin Lou1,4,7,
- Shizhong A. Dai1,4,7,
- Wenqi Shen1,4,7,
- Ying Shi1,4,7,
- Ziyang Zhang1,4,7,
- Inigo Barrio-Hernandez8,
- Danish Memon8,
- Claudia Hernandez-Armenta8,
- Christopher J.P. Mathy1,9,10,2,
- Tina Perica1,2,9,
- Kala B. Pilla1,2,9,
- Sai J. Ganesan1,2,9,
- Daniel J. Saltzberg1,2,9,
- Rakesh Ramachandran1,2,9,
- Xi Liu1,2,6,
- Sara B. Rosenthal11,
- Lorenzo Calviello12,
- Srivats Venkataramanan12,
- Jose Liboy-Lugo12,
- Yizhu Lin12,
- Stephanie A. Wankowicz1,13,9,
- Markus Bohn6,
- Phillip P. Sharp4,
- Raphael Trenker14,
- Janet M. Young15,
- Devin A. Cavero3,
- Joseph Hiatt16,3,
- Theodore L. Roth16,3,
- Ujjwal Rathore3,
- Advait Subramanian1,17,
- Julia Noack1,17,
- Mathieu Hubert18,
- Ferdinand Roesch19,
- Thomas Vallet19,
- Björn Meyer19,
- Kris M. White20,
- Lisa Miorin20,
- Oren S. Rosenberg21,22,23,
- Kliment A Verba1,2,6,
- David Agard1,24,
- Melanie Ott3,21,
- Michael Emerman25,
- Davide Ruggero26,27,4,
- Adolfo García-Sastre20,
- Natalia Jura1,14,4,
- Mark von Zastrow1,14,28,
- Jack Taunton1,2,4,
- Alan Ashworth1,27,
- Olivier Schwartz18,
- Marco Vignuzzi19,
- Christophe d’Enfert29,
- Shaeri Mukherjee1,17,
- Matt Jacobson6,
- Harmit S. Malik15,
- Danica G. Fujimori1,4,6,
- Trey Ideker30,
- Charles S. Craik6,27,
- Stephen Floor12,27,
- James S. Fraser1,2,9,
- John Gross1,2,6,
- Andrej Sali1,2,6,9,
- Tanja Kortemme1,9,10,2,
- Pedro Beltrao8,
- Kevan Shokat1,4,7,
- Brian K. Shoichet1,2,6 and
- Nevan J. Krogan1,2,3,4,*
- 1QBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA
- 2University of California San Francisco, Quantitative Biosciences Institute (QBI), San Francisco, CA, 94158, USA
- 3J. David Gladstone Institutes, San Francisco, CA 94158, USA
- 4University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA
- 5Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA
- 6Department of Pharmaceutical Chemistry, University of California, San Francisco
- 7Howard Hughes Medical Institute
- 8European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
- 9Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
- 10The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, USA
- 11Center for Computational Biology and Bioinformatics, Department of Medicine, University of California San Diego
- 12Department of Cell and Tissue Biology, University of California, San Francisco
- 13Biophysics Graduate Program, University of California, San Francisco
- 14Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, 94158, USA
- 15Division of Basic Sciences, Fred Hutchinson Cancer Research Center
- 16Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA
- 17George William Hooper Foundation, Department of Microbiology and Immunology, UC San Francisco
- 18Virus and Immunity Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
- 19Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France
- 20Department for Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY
- 21Department of Medicine, University of California San Francisco, San Francisco, CA, USA
- 22Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA
- 23Chan-Zuckerberg Biohub
- 24Biochemistry & Biophysics and Quantitative Biosciences Institute UCSF 600 16th St San Francisco, CA 94143
- 25Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103
- 26Department of Urology, University of California, San Francisco, San Francisco, CA, USA
- 27Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, 94158, USA
- 28University of California San Francisco, Department of Psychiatry, San Francisco, CA, 94158, USA
- 29Direction Scientifique, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France
- 30Division of Genetics, Department of Medicine, University of California San Diego
- ↵*Correspondence and requests for materials should be addressed to nevan.krogan{at}ucsf.edu
Posted March 27, 2020.
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Matthew J. O’Meara, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Huettenhain, Robyn M. Kaake, Alicia L. Richards, Beril Tutuncuoglu, Helene Foussard, Jyoti Batra, Kelsey Haas, Maya Modak, Minkyu Kim, Paige Haas, Benjamin J. Polacco, Hannes Braberg, Jacqueline M. Fabius, Manon Eckhardt, Margaret Soucheray, Melanie J. Bennett, Merve Cakir, Michael J. McGregor, Qiongyu Li, Zun Zar Chi Naing, Yuan Zhou, Shiming Peng, Ilsa T. Kirby, James E. Melnyk, John S. Chorba, Kevin Lou, Shizhong A. Dai, Wenqi Shen, Ying Shi, Ziyang Zhang, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Christopher J.P. Mathy, Tina Perica, Kala B. Pilla, Sai J. Ganesan, Daniel J. Saltzberg, Rakesh Ramachandran, Xi Liu, Sara B. Rosenthal, Lorenzo Calviello, Srivats Venkataramanan, Jose Liboy-Lugo, Yizhu Lin, Stephanie A. Wankowicz, Markus Bohn, Phillip P. Sharp, Raphael Trenker, Janet M. Young, Devin A. Cavero, Joseph Hiatt, Theodore L. Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, Ferdinand Roesch, Thomas Vallet, Björn Meyer, Kris M. White, Lisa Miorin, Oren S. Rosenberg, Kliment A Verba, David Agard, Melanie Ott, Michael Emerman, Davide Ruggero, Adolfo García-Sastre, Natalia Jura, Mark von Zastrow, Jack Taunton, Alan Ashworth, Olivier Schwartz, Marco Vignuzzi, Christophe d’Enfert, Shaeri Mukherjee, Matt Jacobson, Harmit S. Malik, Danica G. Fujimori, Trey Ideker, Charles S. Craik, Stephen Floor, James S. Fraser, John Gross, Andrej Sali, Tanja Kortemme, Pedro Beltrao, Kevan Shokat, Brian K. Shoichet, Nevan J. Krogan
bioRxiv 2020.03.22.002386; doi: https://doi.org/10.1101/2020.03.22.002386
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Matthew J. O’Meara, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Huettenhain, Robyn M. Kaake, Alicia L. Richards, Beril Tutuncuoglu, Helene Foussard, Jyoti Batra, Kelsey Haas, Maya Modak, Minkyu Kim, Paige Haas, Benjamin J. Polacco, Hannes Braberg, Jacqueline M. Fabius, Manon Eckhardt, Margaret Soucheray, Melanie J. Bennett, Merve Cakir, Michael J. McGregor, Qiongyu Li, Zun Zar Chi Naing, Yuan Zhou, Shiming Peng, Ilsa T. Kirby, James E. Melnyk, John S. Chorba, Kevin Lou, Shizhong A. Dai, Wenqi Shen, Ying Shi, Ziyang Zhang, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Christopher J.P. Mathy, Tina Perica, Kala B. Pilla, Sai J. Ganesan, Daniel J. Saltzberg, Rakesh Ramachandran, Xi Liu, Sara B. Rosenthal, Lorenzo Calviello, Srivats Venkataramanan, Jose Liboy-Lugo, Yizhu Lin, Stephanie A. Wankowicz, Markus Bohn, Phillip P. Sharp, Raphael Trenker, Janet M. Young, Devin A. Cavero, Joseph Hiatt, Theodore L. Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, Ferdinand Roesch, Thomas Vallet, Björn Meyer, Kris M. White, Lisa Miorin, Oren S. Rosenberg, Kliment A Verba, David Agard, Melanie Ott, Michael Emerman, Davide Ruggero, Adolfo García-Sastre, Natalia Jura, Mark von Zastrow, Jack Taunton, Alan Ashworth, Olivier Schwartz, Marco Vignuzzi, Christophe d’Enfert, Shaeri Mukherjee, Matt Jacobson, Harmit S. Malik, Danica G. Fujimori, Trey Ideker, Charles S. Craik, Stephen Floor, James S. Fraser, John Gross, Andrej Sali, Tanja Kortemme, Pedro Beltrao, Kevan Shokat, Brian K. Shoichet, Nevan J. Krogan
bioRxiv 2020.03.22.002386; doi: https://doi.org/10.1101/2020.03.22.002386
Subject Areas
- Biochemistry (11753)
- Bioengineering (8752)
- Bioinformatics (29201)
- Biophysics (14974)
- Cancer Biology (12100)
- Cell Biology (17413)
- Clinical Trials (138)
- Developmental Biology (9422)
- Ecology (14182)
- Epidemiology (2067)
- Evolutionary Biology (18309)
- Genetics (12245)
- Genomics (16804)
- Immunology (11869)
- Microbiology (28098)
- Molecular Biology (11596)
- Neuroscience (60975)
- Paleontology (451)
- Pathology (1871)
- Pharmacology and Toxicology (3238)
- Physiology (4959)
- Plant Biology (10427)
- Synthetic Biology (2886)
- Systems Biology (7340)
- Zoology (1651)