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Krüppel-Like Factor 14 Improves Cardiac Function After Myocardial Infarction

Yating Wang, Danyan Xu, View ORCID ProfileLi Shen
doi: https://doi.org/10.1101/2020.03.25.008052
Yating Wang
1Department of Cardiovascular Medicine,The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
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Danyan Xu
1Department of Cardiovascular Medicine,The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
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  • For correspondence: shenli6810@163.com xudanyan3507@163.com
Li Shen
1Department of Cardiovascular Medicine,The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
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  • ORCID record for Li Shen
  • For correspondence: shenli6810@163.com xudanyan3507@163.com
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Abstract

Background Reversal of heart failure after myocardial infarction (MI) remains a global challenge. The goal of a clinical physician is to prevent heart failure immediately following the infarct. Since traditional strategies are only partially helpful for improving cardiac function, there is an urgency to identify novel approaches to maintain cardiac function.

Objectives The aim of this study was to determine the role of Krüppel-Like Factor 14 (KLF14) in the heart post-MI.

Methods and Results Wild-type and KLF14 overexpression mice were subjected to MI. At four weeks following MI, the infarct size was significantly reduced, left ventricular fraction shortening was significantly preserved, and left ventricular chamber dilation was attenuated in the KLF14 overexpression group. Transmission electron microscopy studies revealed striking evidence of decreased mitochondrial damage in the KLF14 overexpression myocardium following MI. To gain insight into the underlying relationship between KLF14 and mitochondria, we examined a broad array of genes involved in mitochondrial function and found that KLF14 overexpression was involved in the decreased apoptosis of mitochondria induced by H2O2. This beneficial effect was associated with increased levels of PGC-1α.

Conclusions These results demonstrate that KLF14 plays a critical protective role in the heart after MI by regulating mitochondrial function, which may be achieved by regulating PGC-1α.

  • Abbreviation

    MI
    myocardial infarction
    HDL-C
    high-density lipoprotein cholesterol
    TG
    triglyceride
    GWAS
    Genome-wide association studies
    ASCVD
    atherosclerotic cardiovascular disease
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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    Posted March 25, 2020.
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    Krüppel-Like Factor 14 Improves Cardiac Function After Myocardial Infarction
    Yating Wang, Danyan Xu, Li Shen
    bioRxiv 2020.03.25.008052; doi: https://doi.org/10.1101/2020.03.25.008052
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    Krüppel-Like Factor 14 Improves Cardiac Function After Myocardial Infarction
    Yating Wang, Danyan Xu, Li Shen
    bioRxiv 2020.03.25.008052; doi: https://doi.org/10.1101/2020.03.25.008052

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