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Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients

View ORCID ProfileDavid H. Brann, View ORCID ProfileTatsuya Tsukahara, View ORCID ProfileCaleb Weinreb, Darren W. Logan, View ORCID ProfileSandeep Robert Datta
doi: https://doi.org/10.1101/2020.03.25.009084
David H. Brann
1Harvard Medical School Department of Neurobiology, Boston MA 02115 USA
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Tatsuya Tsukahara
1Harvard Medical School Department of Neurobiology, Boston MA 02115 USA
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Caleb Weinreb
1Harvard Medical School Department of Neurobiology, Boston MA 02115 USA
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Darren W. Logan
2Waltham Petcare Science Institute, Leicestershire LE14 4RT, UK
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Sandeep Robert Datta
1Harvard Medical School Department of Neurobiology, Boston MA 02115 USA
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  • For correspondence: srdatta@hms.harvard.edu
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Abstract

Recent reports suggest an association between COVID-19 and altered olfactory function. Here we analyze bulk and single cell RNA-Seq datasets to identify cell types in the olfactory epithelium that express molecules that mediate infection by SARS-CoV-2 (CoV-2), the causal agent in COVID-19. We find in both mouse and human datasets that olfactory sensory neurons do not express two key genes involved in CoV-2 entry, ACE2 and TMPRSS2. In contrast, olfactory epithelial support cells and stem cells express both of these genes, as do cells in the nasal respiratory epithelium. Taken together, these findings suggest possible mechanisms through which CoV-2 infection could lead to anosmia or other forms of olfactory dysfunction.

Footnotes

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680959/bin/srep18178-s2.xls

  • https://doi.org/10.1371/journal.pone.0113170.s014

  • https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE52464

  • https://advances.sciencemag.org/highwire/filestream/217162/field_highwire_adjunct_files/0/aax0396_Data_file_S1.xlsx

  • https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE139522

  • https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE99251

  • https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE120199

  • https://www.genomique.eu/cellbrowser/HCA/

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Posted March 28, 2020.
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Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients
David H. Brann, Tatsuya Tsukahara, Caleb Weinreb, Darren W. Logan, Sandeep Robert Datta
bioRxiv 2020.03.25.009084; doi: https://doi.org/10.1101/2020.03.25.009084
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Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients
David H. Brann, Tatsuya Tsukahara, Caleb Weinreb, Darren W. Logan, Sandeep Robert Datta
bioRxiv 2020.03.25.009084; doi: https://doi.org/10.1101/2020.03.25.009084

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