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History
- March 29, 2020.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Author Information
- William Cross*,1,2,
- Maximilian Mossner*,1,
- Salpie Nowinski*,1,
- George Cresswell*,3,
- Abhirup Banerjee*,1,
- Marc Williams*,1,4,
- Laura Gay*,1,
- Ann-Marie Baker*,1,
- Christopher Kimberley1,
- Hayley Davis11,
- Pierre Martinez1,5,
- Maria Traki1,
- Viola Walther1,
- Kane Smith1,
- Giulio Caravagna3,
- Sasikumar Amarasingam1,6,
- George Elia1,
- Alison Berner1,2,
- Ryan Changho Choi1,6,7,
- Pradeep Ramagiri8,
- Ritika Chauhan8,
- Nik Matthews8,
- Jamie Murphy9,
- Anthony Antoniou6,
- Susan Clark6,9,
- Jo-Anne Chin Aleong10,
- Enric Domingo11,
- Inmaculada Spiteri3,
- Stuart AC McDonald1,
- Darryl Shibata12,
- Miangela M Lacle13,
- Lai Mun Wang14,15,
- Morgan Moorghen6,
- Ian PM Tomlinson16,
- Marco Novelli2,
- Marnix Jansen2,17,
- Alan Watson18,
- Nicholas A Wright1,
- John Bridgewater2,17,
- Manuel Rodriguez-Justo2,17,
- Hemant Kocher18,10,
- Simon J Leedham14,
- Andrea Sottoriva^,3 and
- Trevor A Graham^,1
- 1Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Sq, London, UK
- 2UCL Cancer Institute, UCL, 72 Huntley St, Bloomsbury, London, UK
- 3Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
- 4Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 321 East 61st St., New York, NY 10065, USA
- 5Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, 69008, France
- 6St Mark’s Hospital, Harrow, London, UK
- 7St. George Hospital, Sydney, Australia
- 8Tumour Profiling Unit (TPU), Institute of Cancer Research, London, UK
- 9Department of Surgery and Cancer, Imperial College London, London, UK
- 10Barts Health NHS Trust, The Royal London Hospital, Whitechapel, London, UK
- 11Department of Oncology, University of Oxford, Oxford
- 12Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
- 13Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands
- 14Wellcome Trust Centre Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
- 15Ludwig Institute, University of Oxford, Oxford, UK
- 16Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
- 17UCL Hospitals NHS Trust, London, UK
- 18Department of Gastroenterology, Barts Health, Whipps Cross Hospital, Leytonstone, London, UK
- 19Centre for Tumour Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Sq, London, UK
- ↵^For correspondence: andrea.sottoriva{at}icr.ac.uk and t.graham{at}qmul.ac.uk
↵* These authors contributed equally to this manuscript.
Contributions: Study conception and design: AS & TG, Funding and supervision: SL, HK, NW, AS, TG, Manuscript writing: WC, MM, SN, GC, MW, AS, TG, Bioinformatics: WC, SN, GC, MW, PM, GC, TG, Mathematical modelling: MW, TG, Experimental work: MM, LG, AB, CK, MT, VW, KS, SA, RC, HD, IS, NM, Provision of patient materials: SA, AB, JM, AA, SC, JC, ED, LM, IT, MM, ML, AW, MN, MRJ, JB, HK, SL Histopathology: MRJ, ML, MJ, NW, MN, LM, MM