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Multimodal brain imaging study of 19,825 participants reveals adverse effects of moderate drinking

Remi Daviet, Gökhan Aydogan, Kanchana Jagannathan, Nathaniel Spilka, Philipp Koellinger, Henry R. Kranzler, Gideon Nave, View ORCID ProfileReagan R. Wetherill
doi: https://doi.org/10.1101/2020.03.27.011791
Remi Daviet
1Marketing Department, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA
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Gökhan Aydogan
2Department of Economics, University of Zurich, Switzerland
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Kanchana Jagannathan
3Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
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Nathaniel Spilka
3Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
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Philipp Koellinger
4Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam
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Henry R. Kranzler
3Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
5Crescenz VAMC, Philadelphia, PA, USA
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Gideon Nave
1Marketing Department, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA
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Reagan R. Wetherill
3Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
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  • ORCID record for Reagan R. Wetherill
  • For correspondence: rweth@pennmedicine.upenn.edu
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ABSTRACT

Alcohol consumption can have significant deleterious consequences, including brain atrophy, neuronal loss, poorer white matter fiber integrity, and cognitive decline, but the effects of light-to-moderate alcohol consumption on brain structure remain unclear. Here we examine the associations between alcohol intake and brain structure using structural, diffusion tensor, and neurite orientation dispersion and density imaging data from 19,825 generally healthy middle-aged and older adults from the UK Biobank. Systematically controlling for potential confounds, we found that greater alcohol consumption was associated with lower global gray and white matter volume, regional gray matter volume in cortical and subcortical areas, and white matter fiber integrity and complexity. Post hoc analyses revealed that these associations were non-linear. Our findings extensively characterize the associations between alcohol intake and gray and white matter macrostructure and microstructure. Consuming two or more units of alcohol per day, equivalent to one drink in some establishments, could have negative effects on brain health, an important public health finding.

One Sentence Summary Moderate alcohol intake, consuming two or more units of alcohol per day, has negative effects on brain health.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted March 30, 2020.
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Multimodal brain imaging study of 19,825 participants reveals adverse effects of moderate drinking
Remi Daviet, Gökhan Aydogan, Kanchana Jagannathan, Nathaniel Spilka, Philipp Koellinger, Henry R. Kranzler, Gideon Nave, Reagan R. Wetherill
bioRxiv 2020.03.27.011791; doi: https://doi.org/10.1101/2020.03.27.011791
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Multimodal brain imaging study of 19,825 participants reveals adverse effects of moderate drinking
Remi Daviet, Gökhan Aydogan, Kanchana Jagannathan, Nathaniel Spilka, Philipp Koellinger, Henry R. Kranzler, Gideon Nave, Reagan R. Wetherill
bioRxiv 2020.03.27.011791; doi: https://doi.org/10.1101/2020.03.27.011791

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