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Prion protein lowering is a disease-modifying therapy across prion strains, disease stages, and endpoints
View ORCID ProfileEric Vallabh Minikel, Hien T Zhao, Jason Le, Jill O’Moore, Rose Pitstick, Samantha Graffam, George A Carlson, Jasna Kriz, Jae Beom Kim, Jiyan Ma, Holger Wille, Judd Aiken, Deborah McKenzie, Katsumi Doh-ura, Matthew Beck, Rhonda O’Keefe, Jacquelyn Stathopoulos, Tyler Caron, Stuart L Schreiber, Jeffrey B Carroll, Holly B Kordasiewicz, Deborah E Cabin, View ORCID ProfileSonia M Vallabh
doi: https://doi.org/10.1101/2020.03.27.011940
Eric Vallabh Minikel
1Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
2Prion Alliance, Cambridge, MA, 02139, USA
3Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, 02114, USA
4Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA
5Harvard Medical School, Boston, MA, 02115, USA
Hien T Zhao
6Ionis Pharmaceuticals Inc, Carlsbad, CA, 92010, USA
Jason Le
7Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
Jill O’Moore
8McLaughlin Research Institute, Great Falls, MT, 59405, USA
Rose Pitstick
8McLaughlin Research Institute, Great Falls, MT, 59405, USA
Samantha Graffam
7Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
George A Carlson
8McLaughlin Research Institute, Great Falls, MT, 59405, USA
Jasna Kriz
9Cervo Brain Research Center, Université Laval, Québec, QC, G1J 2G3, Canada
Jae Beom Kim
10PerkinElmer, Hopkinton, MA, 01748, USA
Jiyan Ma
11Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, 49503, USA
Holger Wille
12University of Alberta, Edmonton, AB, T6G 2M8, Canada
Judd Aiken
12University of Alberta, Edmonton, AB, T6G 2M8, Canada
Deborah McKenzie
12University of Alberta, Edmonton, AB, T6G 2M8, Canada
Katsumi Doh-ura
13Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan
Matthew Beck
7Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
Rhonda O’Keefe
7Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
Jacquelyn Stathopoulos
7Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
Tyler Caron
7Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
Stuart L Schreiber
7Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
14Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA, 02138, USA
Jeffrey B Carroll
15Western Washington University, Bellingham, WA, 98225, USA
Holly B Kordasiewicz
6Ionis Pharmaceuticals Inc, Carlsbad, CA, 92010, USA
Deborah E Cabin
8McLaughlin Research Institute, Great Falls, MT, 59405, USA
Sonia M Vallabh
1Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
2Prion Alliance, Cambridge, MA, 02139, USA
3Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, 02114, USA
4Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA
5Harvard Medical School, Boston, MA, 02115, USA
Posted March 31, 2020.
Prion protein lowering is a disease-modifying therapy across prion strains, disease stages, and endpoints
Eric Vallabh Minikel, Hien T Zhao, Jason Le, Jill O’Moore, Rose Pitstick, Samantha Graffam, George A Carlson, Jasna Kriz, Jae Beom Kim, Jiyan Ma, Holger Wille, Judd Aiken, Deborah McKenzie, Katsumi Doh-ura, Matthew Beck, Rhonda O’Keefe, Jacquelyn Stathopoulos, Tyler Caron, Stuart L Schreiber, Jeffrey B Carroll, Holly B Kordasiewicz, Deborah E Cabin, Sonia M Vallabh
bioRxiv 2020.03.27.011940; doi: https://doi.org/10.1101/2020.03.27.011940
Prion protein lowering is a disease-modifying therapy across prion strains, disease stages, and endpoints
Eric Vallabh Minikel, Hien T Zhao, Jason Le, Jill O’Moore, Rose Pitstick, Samantha Graffam, George A Carlson, Jasna Kriz, Jae Beom Kim, Jiyan Ma, Holger Wille, Judd Aiken, Deborah McKenzie, Katsumi Doh-ura, Matthew Beck, Rhonda O’Keefe, Jacquelyn Stathopoulos, Tyler Caron, Stuart L Schreiber, Jeffrey B Carroll, Holly B Kordasiewicz, Deborah E Cabin, Sonia M Vallabh
bioRxiv 2020.03.27.011940; doi: https://doi.org/10.1101/2020.03.27.011940
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