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HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV

View ORCID ProfileAleksandra Milewska, Ying Chi, Artur Szczepanski, Emilia Barreto-Duran, Kevin Liu, Dan Liu, Xiling Guo, Yiyue Ge, Jingxin Li, Lunbiao Cui, Marek Ochman, Maciej Urlik, Sylwia Rodziewicz-Motowidlo, Fengcai Zhu, Krzysztof Szczubialka, Maria Nowakowska, View ORCID ProfileKrzysztof Pyrc
doi: https://doi.org/10.1101/2020.03.29.014183
Aleksandra Milewska
aVirogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland
bMicrobiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland
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  • ORCID record for Aleksandra Milewska
  • For correspondence: k.a.pyrc@uj.edu.pl maria.nowakowska@uj.edu.pl krzysztof.szczubialka@uj.edu.pl jszfc@vip.sina.com aleksandra.milewska@uj.edu.pl
Ying Chi
cNHC Key Lab of Enteric Pathogenic Microbiology, Jiangsu Provincial Centre for Disease Control & Prevention. 172 Jiangsu Rd., Nanjing, Jiangsu, 210009, PR China
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Artur Szczepanski
aVirogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland
bMicrobiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland
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Emilia Barreto-Duran
aVirogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland
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Kevin Liu
dNanjing Techboon Institute of Clinical Medicine. #1003, Tower B of Yangtze Sci. & Tech. Innovation Centre, 211 Pubing Rd., Nanjing, Jiangsu, 211800, PR China
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Dan Liu
dNanjing Techboon Institute of Clinical Medicine. #1003, Tower B of Yangtze Sci. & Tech. Innovation Centre, 211 Pubing Rd., Nanjing, Jiangsu, 211800, PR China
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Xiling Guo
cNHC Key Lab of Enteric Pathogenic Microbiology, Jiangsu Provincial Centre for Disease Control & Prevention. 172 Jiangsu Rd., Nanjing, Jiangsu, 210009, PR China
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Yiyue Ge
cNHC Key Lab of Enteric Pathogenic Microbiology, Jiangsu Provincial Centre for Disease Control & Prevention. 172 Jiangsu Rd., Nanjing, Jiangsu, 210009, PR China
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Jingxin Li
cNHC Key Lab of Enteric Pathogenic Microbiology, Jiangsu Provincial Centre for Disease Control & Prevention. 172 Jiangsu Rd., Nanjing, Jiangsu, 210009, PR China
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Lunbiao Cui
cNHC Key Lab of Enteric Pathogenic Microbiology, Jiangsu Provincial Centre for Disease Control & Prevention. 172 Jiangsu Rd., Nanjing, Jiangsu, 210009, PR China
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Marek Ochman
eDepartment of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland
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Maciej Urlik
eDepartment of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland
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Sylwia Rodziewicz-Motowidlo
fDepartment of Biomedical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland
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Fengcai Zhu
cNHC Key Lab of Enteric Pathogenic Microbiology, Jiangsu Provincial Centre for Disease Control & Prevention. 172 Jiangsu Rd., Nanjing, Jiangsu, 210009, PR China
hCentre for Global Health, Nanjing Medical University. 18 Tianyuan Rd. E., Nanjing, Jiangsu, 210009, PR China
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  • For correspondence: k.a.pyrc@uj.edu.pl maria.nowakowska@uj.edu.pl krzysztof.szczubialka@uj.edu.pl jszfc@vip.sina.com aleksandra.milewska@uj.edu.pl
Krzysztof Szczubialka
gDepartment of Physical Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Krakow, Poland
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  • For correspondence: k.a.pyrc@uj.edu.pl maria.nowakowska@uj.edu.pl krzysztof.szczubialka@uj.edu.pl jszfc@vip.sina.com aleksandra.milewska@uj.edu.pl
Maria Nowakowska
gDepartment of Physical Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Krakow, Poland
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  • For correspondence: k.a.pyrc@uj.edu.pl maria.nowakowska@uj.edu.pl krzysztof.szczubialka@uj.edu.pl jszfc@vip.sina.com aleksandra.milewska@uj.edu.pl
Krzysztof Pyrc
aVirogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland
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  • For correspondence: k.a.pyrc@uj.edu.pl maria.nowakowska@uj.edu.pl krzysztof.szczubialka@uj.edu.pl jszfc@vip.sina.com aleksandra.milewska@uj.edu.pl
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ABSTRACT

The beginning of 2020 brought us information about the novel coronavirus emerging in China. Rapid research resulted in the characterization of the pathogen, which appeared to be a member of the SARS-like cluster, commonly seen in bats. Despite the global and local efforts, the virus escaped the healthcare measures and rapidly spread in China and later globally, officially causing a pandemic and global crisis in March 2020. At present, different scenarios are being written to contain the virus, but the development of novel anticoronavirals for all highly pathogenic coronaviruses remains the major challenge. Here, we describe the antiviral activity of previously developed by us HTCC compound (N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride), which may be used as potential inhibitor of currently circulating highly pathogenic coronaviruses – SARS-CoV-2 and MERS-CoV.

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Posted March 31, 2020.
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HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV
Aleksandra Milewska, Ying Chi, Artur Szczepanski, Emilia Barreto-Duran, Kevin Liu, Dan Liu, Xiling Guo, Yiyue Ge, Jingxin Li, Lunbiao Cui, Marek Ochman, Maciej Urlik, Sylwia Rodziewicz-Motowidlo, Fengcai Zhu, Krzysztof Szczubialka, Maria Nowakowska, Krzysztof Pyrc
bioRxiv 2020.03.29.014183; doi: https://doi.org/10.1101/2020.03.29.014183
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HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV
Aleksandra Milewska, Ying Chi, Artur Szczepanski, Emilia Barreto-Duran, Kevin Liu, Dan Liu, Xiling Guo, Yiyue Ge, Jingxin Li, Lunbiao Cui, Marek Ochman, Maciej Urlik, Sylwia Rodziewicz-Motowidlo, Fengcai Zhu, Krzysztof Szczubialka, Maria Nowakowska, Krzysztof Pyrc
bioRxiv 2020.03.29.014183; doi: https://doi.org/10.1101/2020.03.29.014183

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