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SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation

Qiang Zhang, Huajun Zhang, Kun Huang, Yong Yang, Xianfeng Hui, Jindong Gao, Xinglin He, Chengfei Li, Wenxiao Gong, Yufei Zhang, Cheng Peng, Xiaoxiao Gao, Huanchun Chen, Zhong Zou, Zhengli Shi, Meilin Jin
doi: https://doi.org/10.1101/2020.04.01.021196
Qiang Zhang
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
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Huajun Zhang
4CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430070, China
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Kun Huang
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
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Yong Yang
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
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Xianfeng Hui
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
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Jindong Gao
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
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Xinglin He
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
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Chengfei Li
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
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Wenxiao Gong
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
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Yufei Zhang
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
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Cheng Peng
4CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430070, China
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Xiaoxiao Gao
4CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430070, China
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Huanchun Chen
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
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Zhong Zou
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
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  • For correspondence: jml8328@126.com zz19841024@126.com zlshi@wh.iov.cn
Zhengli Shi
4CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430070, China
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  • For correspondence: jml8328@126.com zz19841024@126.com zlshi@wh.iov.cn
Meilin Jin
1National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China
2College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China
3Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, Wuhan, 430070, China
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  • For correspondence: jml8328@126.com zz19841024@126.com zlshi@wh.iov.cn
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Summary

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, and rapidly spread worldwide. Previous studies suggested cat could be a potential susceptible animal of SARS-CoV-2. Here, we investigated the infection of SARS-CoV-2 in cats by detecting specific serum antibodies. A cohort of serum samples were collected from cats in Wuhan, including 102 sampled after COVID-19 outbreak, and 39 prior to the outbreak. 15 of 102 (14.7%) cat sera collected after the outbreak were positive for the receptor binding domain (RBD) of SARS-CoV-2 by indirect enzyme linked immunosorbent assay (ELISA). Among the positive samples, 11 had SARS-CoV-2 neutralizing antibodies with a titer ranging from 1/20 to 1/1080. No serological cross-reactivity was detected between the SARS-CoV-2 and type I or II feline infectious peritonitis virus (FIPV). Our data demonstrates that SARS-CoV-2 has infected cat population in Wuhan during the outbreak.

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Posted April 03, 2020.
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SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation
Qiang Zhang, Huajun Zhang, Kun Huang, Yong Yang, Xianfeng Hui, Jindong Gao, Xinglin He, Chengfei Li, Wenxiao Gong, Yufei Zhang, Cheng Peng, Xiaoxiao Gao, Huanchun Chen, Zhong Zou, Zhengli Shi, Meilin Jin
bioRxiv 2020.04.01.021196; doi: https://doi.org/10.1101/2020.04.01.021196
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SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation
Qiang Zhang, Huajun Zhang, Kun Huang, Yong Yang, Xianfeng Hui, Jindong Gao, Xinglin He, Chengfei Li, Wenxiao Gong, Yufei Zhang, Cheng Peng, Xiaoxiao Gao, Huanchun Chen, Zhong Zou, Zhengli Shi, Meilin Jin
bioRxiv 2020.04.01.021196; doi: https://doi.org/10.1101/2020.04.01.021196

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