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History
- April 6, 2020.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Author Information
- Lasse Folkersen1,2,*,†,
- Stefan Gustafsson3,*,
- Qin Wang4,5,*,
- Daniel Hvidberg Hansen6,
- Åsa K Hedman2,7,
- Andrew Schork1,8,
- Karen Page9,
- Daria V Zhernakova10,
- Yang Wu11,
- James Peters12,
- Niclas Ericsson13,
- Sarah E Bergen14,
- Thibaud Boutin15,
- Andrew D Bretherick15,
- Stefan Enroth16,
- Anettne Kalnapenkis17,
- Jesper R Gådin2,
- Bianca Suur18,
- Yan Chen2,
- Ljubica Matic18,
- Jeremy D Gale19,
- Julie Lee9,
- Weidong Zhang20,
- Amira Quazi9,
- Mika Ala-Korpela4,5,21,
- Seung Hoan Choi22,
- Annique Claringbould10,
- John Danesh12,
- George Davey-Smith23,
- Federico de Masi6,
- Sölve Elmståhl24,
- Gunnar Engström24,
- Eric Fauman25,
- Celine Fernandez24,
- Lude Franke10,
- Paul Franks26,
- Vilmantas Giedraitis27,
- Chris Haley15,
- Anders Hamsten2,
- Andres Ingason1,
- Åsa Johansson16,
- Peter K Joshi28,
- Lars Lind29,
- Cecilia M. Lindgren30,31,22,
- Steven Lubitz32,22,
- Tom Palmer33,
- Erin Macdonald-Dunlop28,
- Martin Magnusson34,35,
- Olle Melander24,
- Karl Michaelsson36,
- Andrew P. Morris37,38,31,
- Reedik Mägi17,
- Michael Nagle25,
- Peter M Nilsson24,
- Jan Nilsson24,
- Marju Orho-Melander39,
- Ozren Polasek40,
- Bram Prins12,
- Erik Pålsson41,
- Ting Qi11,
- Marketa Sjögren24,
- Johan Sundström42,
- Praveen Surendran12,
- Urmo Võsa17,
- Thomas Werge1,
- Rasmus Wernersson6,
- Harm-Jan Westra10,
- Jian Yang11,43,
- Alexandra Zhernakova10,
- Johan Ärnlöv44,
- Jingyuan Fu10,
- Gustav Smith45,
- Tonu Esko17,22,
- Caroline Hayward15,
- Ulf Gyllensten16,
- Mikael Landen41,
- Agneta Siegbahn46,
- Jim F Wilson28,15,
- Lars Wallentin47,
- Adam S Butterworth12,
- Michael V Holmes48,*,
- Erik Ingelsson49,* and
- Anders Mälarstig2,50,*
- 1Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region, Roskilde, Denmark
- 2Department of Medicine, Solna, Karolinska Institute, Sweden
- 3Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
- 4Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia
- 5Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland
- 6Intomics, Lottenborgvej 26, 2800 Lyngby (Copenhagen), Denmark
- 7Pfizer Worldwide Research & Development, Cambridge, MA, USA
- 8Neurogenomics Division, The Translational Genomics Research Institute (TGEN), Phoenix, AZ, USA
- 9Early Clinical Development, Pfizer Worldwide Research & Development, Cambridge, MA, USA
- 10Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
- 11Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
- 12BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom
- 13Deparment of Medical Sciences, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
- 14Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- 15MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland
- 16Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala, Box 815, Uppsala University, SE-75108 Uppsala, Sweden
- 17Estonian Genome Center, Institute of Genomics, University of Tartu 51010, Estonia
- 18Department of Molecular Medicine and Surgery, Solna, Karolinska Institute, Sweden
- 19Inflammation and Immunology Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, USA
- 20Pfizer Global Product Development, Cambridge, MA, USA
- 21NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
- 22Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
- 23MRC Integrative Epidemiology Unit, University of Bristol, UK
- 24Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
- 25Internal Medicine Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, USA
- 26Lund University Diabetes Center, Department of Clinical Sciences, Malmö, Sweden
- 27Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden
- 28Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
- 29Department of Medical Sciences, Uppsala University, Uppsala, Sweden
- 30Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom
- 31Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- 32Cardiovascular Research Center, Massachusetts General Hospital, United States
- 33Department of Mathematics and Statistics, University of Lancaster, Lancaster, UK
- 34Department of Cardiology, Skåne University Hospital Malmö, Malmö, Sweden
- 35Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden
- 36Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
- 37Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK
- 38Department of Biostatistics, University of Liverpool, Liverpool, UK
- 39Department of Clinical Sciences, Clinical Research Center, Lund University, Malmö, Sweden
- 40Faculty of Medicine, University of Split, Split, Croatia
- 41Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
- 42Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden; and The George Institute for Global Health, University of New South Wales, Sydney, Australia
- 43Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
- 44Department of Neurobiology, Care Sciences and Society (NVS), Division of Family Medicine and Primary Care, Karolinska Institutet, Sweden
- 45Department of Cardiology, Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden
- 46Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
- 47Deparment of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
- 48Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
- 49Department of Medicine, Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University School of Medicine, 300 Pasteur Drive, CV 273, Stanford, CA, 94305, USA
- 50Emerging Science & Innovation, Pfizer Worldwide Research & Development, Cambridge, MA, USA
- ↵† Corresponding author; email: lasse.folkersen{at}regionh.dk
↵* these authors contributed equally