Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production

Natalia Fintelman-Rodrigues; Carolina Q. Sacramento; Carlyle Ribeiro Lima; Franklin Souza da Silva; André C. Ferreira; Mayara Mattos; Caroline S. de Freitas; Vinicius Cardoso Soares; Suelen da Silva Gomes Dias; Jairo R. Temerozo; Milene Miranda; Aline R. Matos; Fernando A. Bozza; Nicolas Carels; Carlos Roberto Alves; Marilda M. Siqueira; Patrícia T. Bozza; Thiago Moreno L. Souza

doi:10.1101/2020.04.04.020925

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Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production

Natalia Fintelman-Rodrigues, Carolina Q. Sacramento, Carlyle Ribeiro Lima, Franklin Souza da Silva, André C. Ferreira, Mayara Mattos, Caroline S. de Freitas, Vinicius Cardoso Soares, Suelen da Silva Gomes Dias, Jairo R. Temerozo, Milene Miranda, Aline R. Matos, Fernando A. Bozza, Nicolas Carels, Carlos Roberto Alves, Marilda M. Siqueira, Patrícia T. Bozza, View ORCID ProfileThiago Moreno L. Souza

doi: https://doi.org/10.1101/2020.04.04.020925

Natalia Fintelman-Rodrigues

1Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil

8Instituto D’or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil

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Carolina Q. Sacramento

1Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil

8Instituto D’or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil

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Carlyle Ribeiro Lima

8Instituto D’or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil

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Franklin Souza da Silva

2Laboratório de Biologia Molecular e Doenças Endêmicas, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil

8Instituto D’or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil

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André C. Ferreira

1Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil

3Universidade Iguaçu, Nova Iguaçu, RJ, Brazil

8Instituto D’or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil

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Mayara Mattos

1Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil

8Instituto D’or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil

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Caroline S. de Freitas

1Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil

8Instituto D’or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil

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Vinicius Cardoso Soares

1Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil

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Suelen da Silva Gomes Dias

1Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil

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Jairo R. Temerozo

4Laboratório de Pesquisas em Timo, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil

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Milene Miranda

5Laboratório de Vírus Respiratório e do Sarampo, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil

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Aline R. Matos

5Laboratório de Vírus Respiratório e do Sarampo, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil

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Fernando A. Bozza

6National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDNP), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil

7Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, RJ, Brazil

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Nicolas Carels

8Instituto D’or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil

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Carlos Roberto Alves

2Laboratório de Biologia Molecular e Doenças Endêmicas, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil

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Marilda M. Siqueira

5Laboratório de Vírus Respiratório e do Sarampo, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil

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Patrícia T. Bozza

1Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil

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Thiago Moreno L. Souza

1Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil

8Instituto D’or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil

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ORCID record for Thiago Moreno L. Souza
For correspondence: tmoreno@cdts.fiocruz.br

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Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production

bioRxiv 2020.04.04.020925; doi: https://doi.org/10.1101/2020.04.04.020925

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Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production

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