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Neural control of steering in walking Drosophila

Aleksandr Rayshubskiy, Stephen L. Holtz, Isabel D’Alessandro, Anna A. Li, Quinn X. Vanderbeck, Isabel S. Haber, Peter W. Gibb, Rachel I. Wilson
doi: https://doi.org/10.1101/2020.04.04.024703
Aleksandr Rayshubskiy
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA
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Stephen L. Holtz
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA
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Isabel D’Alessandro
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA
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Anna A. Li
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA
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Quinn X. Vanderbeck
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA
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Isabel S. Haber
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA
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Peter W. Gibb
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA
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Rachel I. Wilson
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA
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  • For correspondence: rachel_wilson@hms.harvard.edu
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Abstract

During navigation, the brain must continuously integrate external guidance cues with internal spatial maps to update steering commands. However, it has been difficult to link spatial maps with motor control. Here we identify descending “steering” neurons in the Drosophila brain that lie two synapses downstream from the brain’s heading direction map in the central complex. These steering neurons predict behavioral turns caused by microstimulation of the spatial map. Moreover, these neurons receive “direct” sensory input that bypasses the central complex, and they predict steering evoked by multimodal stimuli. Unilateral activation of these neurons can promote turning, while bilateral silencing interferes with body and leg movements. In short, these neurons combine internal maps with external cues to predict and influence steering. They represent a key link between cognitive maps, which use an abstract coordinate frame, and motor commands, which use a body-centric coordinate frame.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 05, 2020.
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Neural control of steering in walking Drosophila
Aleksandr Rayshubskiy, Stephen L. Holtz, Isabel D’Alessandro, Anna A. Li, Quinn X. Vanderbeck, Isabel S. Haber, Peter W. Gibb, Rachel I. Wilson
bioRxiv 2020.04.04.024703; doi: https://doi.org/10.1101/2020.04.04.024703
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Neural control of steering in walking Drosophila
Aleksandr Rayshubskiy, Stephen L. Holtz, Isabel D’Alessandro, Anna A. Li, Quinn X. Vanderbeck, Isabel S. Haber, Peter W. Gibb, Rachel I. Wilson
bioRxiv 2020.04.04.024703; doi: https://doi.org/10.1101/2020.04.04.024703

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