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Natural gene drives offer potential pathogen control strategies in plants

View ORCID ProfileDonald M. Gardiner, Anca Rusu, Luke Barrett, Gavin C. Hunter, Kemal Kazan
doi: https://doi.org/10.1101/2020.04.05.026500
Donald M. Gardiner
1Commonwealth Scientific and Industrial Research Organisation (CSIRO), Agriculture and Food, 306 Carmody Road, St Lucia, Queensland, 4067, Australia
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  • ORCID record for Donald M. Gardiner
  • For correspondence: Donald.Gardiner@csiro.au
Anca Rusu
1Commonwealth Scientific and Industrial Research Organisation (CSIRO), Agriculture and Food, 306 Carmody Road, St Lucia, Queensland, 4067, Australia
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Luke Barrett
2Commonwealth Scientific and Industrial Research Organisation (CSIRO), Black Mountain Science and Innovation Park, Agriculture and Food, Clunies Ross Street, Acton 2601, Australian Capital Territory, Australia
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Gavin C. Hunter
3Commonwealth Scientific and Industrial Research Organisation (CSIRO), Health and Biosecurity, Black Mountain Science and Innovation Park, Clunies Ross Street, Acton 2601, Australian Capital Territory, Australia
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Kemal Kazan
1Commonwealth Scientific and Industrial Research Organisation (CSIRO), Agriculture and Food, 306 Carmody Road, St Lucia, Queensland, 4067, Australia
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Summary

  • Globally, fungal pathogens cause enormous crop losses and current control practices are not always effective, economical or environmentally sustainable. Tools enabling genetic management of wild pathogen populations could potentially solve many problems associated with plant diseases.

  • A natural gene drive from a heterologous species can be used in the globally important cereal pathogen, Fusarium graminearum, to remove pathogenic traits from contained populations of the fungus. The gene drive element became fixed in a freely crossing populations in only three generations.

  • Repeat induce point mutation, a natural genome defence mechanism in fungi, may be useful to recall the gene drive following release, should a failsafe mechanism be required.

  • We propose that gene drive technology is a potential tool to control plant pathogens.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 06, 2020.
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Natural gene drives offer potential pathogen control strategies in plants
Donald M. Gardiner, Anca Rusu, Luke Barrett, Gavin C. Hunter, Kemal Kazan
bioRxiv 2020.04.05.026500; doi: https://doi.org/10.1101/2020.04.05.026500
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Natural gene drives offer potential pathogen control strategies in plants
Donald M. Gardiner, Anca Rusu, Luke Barrett, Gavin C. Hunter, Kemal Kazan
bioRxiv 2020.04.05.026500; doi: https://doi.org/10.1101/2020.04.05.026500

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