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Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus

View ORCID ProfileSarah Temmam, Alix Barbarino, Djérène Maso, Sylvie Behillil, View ORCID ProfileVincent Enouf, View ORCID ProfileChristèle Huon, Ambre Jaraud, View ORCID ProfileLucie Chevallier, Marija Backovic, Philippe Pérot, View ORCID ProfilePatrick Verwaerde, View ORCID ProfileLaurent Tiret, View ORCID ProfileSylvie van der Werf, Marc Eloit
doi: https://doi.org/10.1101/2020.04.07.029090
Sarah Temmam
1Institut Pasteur, Pathogen Discovery Laboratory, Paris, France
2Institut Pasteur, The OIE Collaborating Centre for Detection and Identification in Humans of Emerging Animal Pathogens, Paris, France
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Alix Barbarino
3Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France
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Djérène Maso
3Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France
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Sylvie Behillil
4Institut Pasteur, National Reference Center for Respiratory Viruses, Molecular Genetics of RNA Viruses, CNRS-UMR 3569, Univ Paris, Paris, France
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Vincent Enouf
4Institut Pasteur, National Reference Center for Respiratory Viruses, Molecular Genetics of RNA Viruses, CNRS-UMR 3569, Univ Paris, Paris, France
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Christèle Huon
1Institut Pasteur, Pathogen Discovery Laboratory, Paris, France
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Ambre Jaraud
3Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France
5Univ Paris Est Creteil, INSERM, IMRB, Creteil, France
6EFS, IMRB, Creteil, France
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Lucie Chevallier
3Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France
5Univ Paris Est Creteil, INSERM, IMRB, Creteil, France
6EFS, IMRB, Creteil, France
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Marija Backovic
7Institut Pasteur, Unité de Virologie Structurale - CNRS, UMR3569, Paris, France
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Philippe Pérot
1Institut Pasteur, Pathogen Discovery Laboratory, Paris, France
2Institut Pasteur, The OIE Collaborating Centre for Detection and Identification in Humans of Emerging Animal Pathogens, Paris, France
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Patrick Verwaerde
3Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France
5Univ Paris Est Creteil, INSERM, IMRB, Creteil, France
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Laurent Tiret
3Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France
5Univ Paris Est Creteil, INSERM, IMRB, Creteil, France
6EFS, IMRB, Creteil, France
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Sylvie van der Werf
4Institut Pasteur, National Reference Center for Respiratory Viruses, Molecular Genetics of RNA Viruses, CNRS-UMR 3569, Univ Paris, Paris, France
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Marc Eloit
1Institut Pasteur, Pathogen Discovery Laboratory, Paris, France
2Institut Pasteur, The OIE Collaborating Centre for Detection and Identification in Humans of Emerging Animal Pathogens, Paris, France
3Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France
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  • For correspondence: marc.eloit@pasteur.fr
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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, in 2019, is responsible for the COVID-19 pandemic. It is now accepted that the wild fauna, probably bats, constitute the initial reservoir of the virus, but little is known about the role pets can play in the spread of the disease in human communities, knowing the ability of SARS-CoV-2 to infect some domestic animals. We tested 21 domestic pets (9 cats and 12 dogs) living in close contact with their owners (belonging to a veterinary community of 20 students) in which two students tested positive for COVID-19 and several others (n = 11/18) consecutively showed clinical signs (fever, cough, anosmia, etc.) compatible with COVID-19 infection. Although a few pets presented many clinical signs indicative for a coronavirus infection, no animal tested positive for SARS-CoV-2 by RT-PCR and no antibodies against SARS-CoV-2 were detectable in their blood using an immunoprecipitation assay. These original data can serve a better evaluation of the host range of SARS-CoV-2 in natural environment exposure conditions.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 09, 2020.
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Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus
Sarah Temmam, Alix Barbarino, Djérène Maso, Sylvie Behillil, Vincent Enouf, Christèle Huon, Ambre Jaraud, Lucie Chevallier, Marija Backovic, Philippe Pérot, Patrick Verwaerde, Laurent Tiret, Sylvie van der Werf, Marc Eloit
bioRxiv 2020.04.07.029090; doi: https://doi.org/10.1101/2020.04.07.029090
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Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus
Sarah Temmam, Alix Barbarino, Djérène Maso, Sylvie Behillil, Vincent Enouf, Christèle Huon, Ambre Jaraud, Lucie Chevallier, Marija Backovic, Philippe Pérot, Patrick Verwaerde, Laurent Tiret, Sylvie van der Werf, Marc Eloit
bioRxiv 2020.04.07.029090; doi: https://doi.org/10.1101/2020.04.07.029090

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