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The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in human and mouse brain

Rongrong Chen, Keer Wang, Jie Yu, Derek Howard, Leon French, Zhong Chen, Chengping Wen, View ORCID ProfileZhenghao Xu
doi: https://doi.org/10.1101/2020.04.07.030650
Rongrong Chen
1Institute of TCM Clinical Basic Medicine, School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
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Keer Wang
1Institute of TCM Clinical Basic Medicine, School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
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Jie Yu
1Institute of TCM Clinical Basic Medicine, School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
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Derek Howard
2Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
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Leon French
2Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
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Zhong Chen
3Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
4Key Laboratory of Medical Neurobiology of National Health Commission and Chinese Academy of Medical Sciences, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Chengping Wen
1Institute of TCM Clinical Basic Medicine, School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
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  • For correspondence: wengcp@163.com xuzhenghao@zcmu.edu.cn
Zhenghao Xu
1Institute of TCM Clinical Basic Medicine, School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
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  • ORCID record for Zhenghao Xu
  • For correspondence: wengcp@163.com xuzhenghao@zcmu.edu.cn
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Article Information

doi 
https://doi.org/10.1101/2020.04.07.030650
History 
  • June 15, 2020.

Article Versions

  • Version 1 (April 9, 2020 - 12:54).
  • Version 2 (May 19, 2020 - 01:21).
  • You are viewing Version 3, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Rongrong Chen1,
  2. Keer Wang1,
  3. Jie Yu1,
  4. Derek Howard2,
  5. Leon French2,
  6. Zhong Chen3,4,
  7. Chengping Wen1,* and
  8. Zhenghao Xu1,*
  1. 1Institute of TCM Clinical Basic Medicine, School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
  2. 2Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
  3. 3Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
  4. 4Key Laboratory of Medical Neurobiology of National Health Commission and Chinese Academy of Medical Sciences, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China
  1. ↵*Corresponding Author: Chengping Wen, PhD, MD. Binwen Road 548, Hangzhou, Zhejiang, China, tel & fax: +86-571-86613587, e-mail: wengcp{at}163.com, Zhenghao Xu, PhD. Binwen Road 548, Hangzhou, Zhejiang, China, tel & fax: +86-571-86613587, e-mail: xuzhenghao{at}zcmu.edu.cn;
  1. The first three authors contribute equally.

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Posted June 15, 2020.
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The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in human and mouse brain
Rongrong Chen, Keer Wang, Jie Yu, Derek Howard, Leon French, Zhong Chen, Chengping Wen, Zhenghao Xu
bioRxiv 2020.04.07.030650; doi: https://doi.org/10.1101/2020.04.07.030650
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The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in human and mouse brain
Rongrong Chen, Keer Wang, Jie Yu, Derek Howard, Leon French, Zhong Chen, Chengping Wen, Zhenghao Xu
bioRxiv 2020.04.07.030650; doi: https://doi.org/10.1101/2020.04.07.030650

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