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Reversed sex-biased mutation rates for indels and base substitutions in Drosophila melanogaster

View ORCID ProfileLauri Törmä, View ORCID ProfileClaire Burny, View ORCID ProfileChristian Schlötterer
doi: https://doi.org/10.1101/2020.04.08.031336
Lauri Törmä
1Institut für Populationsgenetik, Vetmeduni Vienna, Vienna, Austria
2Vienna Graduate School of Population Genetics, Vetmeduni Vienna, Vienna, Austria
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  • ORCID record for Lauri Törmä
Claire Burny
1Institut für Populationsgenetik, Vetmeduni Vienna, Vienna, Austria
2Vienna Graduate School of Population Genetics, Vetmeduni Vienna, Vienna, Austria
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Christian Schlötterer
1Institut für Populationsgenetik, Vetmeduni Vienna, Vienna, Austria
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  • For correspondence: christian.schloetterer@vetmeduni.ac.at
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Abstract

Sex biases in mutation rates may affect the rate of adaptive evolution. In many species, males have higher mutation rates than females when single nucleotide variants (SNVs) are considered. In contrast, indel mutations in humans and chimpanzees are female-biased. In Drosophila melanogaster, direct estimates of mutation rates did not uncover sex differences, but a recent analysis suggested the presence of male-biased SNVs mutations. Here we study the sex-specific mutation processes using mutation accumulation data from mismatch-repair deficient D. melanogaster. We find that sex differences in flies are similar to the ones observed in humans: a higher mutation rate for SNVs in males and a higher indel rate in females. These results have major implications for the study of neutral variation and adaptation in Drosophila.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 09, 2020.
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Reversed sex-biased mutation rates for indels and base substitutions in Drosophila melanogaster
Lauri Törmä, Claire Burny, Christian Schlötterer
bioRxiv 2020.04.08.031336; doi: https://doi.org/10.1101/2020.04.08.031336
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Reversed sex-biased mutation rates for indels and base substitutions in Drosophila melanogaster
Lauri Törmä, Claire Burny, Christian Schlötterer
bioRxiv 2020.04.08.031336; doi: https://doi.org/10.1101/2020.04.08.031336

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